Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-09-08
2000-07-18
Priebe, Scott D.
Chemistry: molecular biology and microbiology
Vector, per se
435 914, 435325, 435455, 514 44, 514642, 536 231, C12N 1500, A61K 4800
Patent
active
060906197
ABSTRACT:
The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.
REFERENCES:
patent: 5277897 (1994-01-01), Piwnica-Worms et al.
patent: 5527928 (1996-06-01), Nantz et al.
patent: 5569754 (1996-10-01), Williams et al.
patent: 5674908 (1997-10-01), Haces et al.
Webster's II New Riverside University Dictionary, p. 67, col. 2, 1994.
Collombet et al., (Molecular Medicine Today, vol. 4, 1:31-38), 1998.
Seibel et al. (Nucleic acids Res. vol. 23, 1, 10-17, 1995).
Murphy Trends in Biotechnology, 15, 8, 326-30, 1997.
Weissig, Volkmar, Jurgen Lasch, Gregory Erdos, Helmut W. Meyer, Thomas C. Rowe, Jeffrey Hughes (1998) "DQAsomes: A Novel Potential Drug and Gene Delivery System Made from Dequalinium.TM." Pharmaceutical Research 15(2):334-337.
Ledley, Fred D. (1996) "Pharmaceutical Approach to Somatic Gene Therapy" Pharmaceutical Research 13(11):1595-1614.
Capecchi, Mario R. (1980) "High Efficiency Transformation by Direct Microinjection of DNA into Cultured Mammalian Cells" Cell 22:479-488.
Weiss et al. (1987) "Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial acculation" Proc. Natl. Acad. Sci. USA 84:5444-5448.
Sompayrac, Lauren M. and Kathleen J. Danna (1981) "Efficient infection of monkey cells with DNA of simian virus 40" Proc. Natl. Acad. Sci. USA 78(12):7575-7578.
Rotenberg, Susan A., Stephen Smiley, Marius Ueffing, Robert S. Krauss, Lan Bo Chen, I. Bernard Weinstein (1990) "Inhibition of Rodent Protein Kinase C by the Anticarcinoma Agent Dequalinium" Cancer Research 50:677-685.
Chen, Claudia and Hiroto Okayama (1987) "High-Efficiency Transformation of Mammalian Cells by Plasmid DNA" Molecular and Cellular Biology 7(8):2745-2752.
Chang, David D. and David A. Clayton (1987) "A Mammalian Mitochondrial RNA Processing Activity Contains Nucleus-Encoded RNA" Science 235:1178-1184.
Zhou, Shaoqui and William S. Allison (1988) "Inhibition And Photoinactivation Of The Bovine Heart Mitochondrial F.sub.1 -A Tphase By The Cytotoxic Agent, Dequalinium" Biochemical and Biophusical Research Communications 152(3):968-972.
Vercesi et al. (1991) "Digitonin Permeabilization Does Not Affect Mitochondrial Function And Allows The Determination Of The Mitochondrial Membrane Potential of Trypanosoma cruzi in Situ" J. Biological Chemistry 266(22):14431-14434.
Vestweber, Dietmar and Gottfried Schatz (1989) "DNA-protein conjugates can enter mitochondria via the protein import pathway" Nature 338:170-172.
Seibel et al. (1995) "Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases" Nucleic Acids Research 23(1):10-17.
Johnson, Lincoln V., Marcia L. Walsh, Beverly J. Bockus, Lan Bo Chen (1981) "Monitoring of Relative Mitochondrial Membrane Potential in Living Cells by Fluorescence Microscopy" J. of Cell Biology 88:526-535.
Li et al. (1994) "Subcellular Partitioning of MRP RNA Assessed by Ultrastructural and Biochemical Analysis" J. of Cell Biology 124(6):871-882.
Bodden, William L., Sanjeewani T. Palayoor, William N. Hait (1986) "Selective Antimitochondrial Agents Inhibit Calmodulin" Biochemical and Biophysical Research 135(2):574-582.
Schreier et al. (1992) "Toxin And Gene Delivery With Artificial Viral Envelopes In Vitro" Proceed. Intern. Symp. Control Rel. Bioact. Mater 19:70-71.
Wallace, Douglas C. (1994) "Mitochondrial DNA Mutations in Diseases of Energy Metabolism" J. of Bioenergetics and Biomembranes 26(3):241-250.
Aubin, Remy J., Michael Weinfeld, Malcolm C. Paterson (1988) "Factors Influencing Efficiency and Reproducibilty of Polybrene-Assisted Gene Transfer" Somatic Cell and Molecular Genetics 14(2):155-167.
Babbs, M., H.O.J. Collier, W.C. Austin, M.D. Potter, E.P. Taylor (1955) "Salts Of Decamethylene-BIS-4-Aminoquinaldinium "Dequadin"), A New Antimicrobial Agent" J. Pharm. Pharmacol. 8:110-119.
Ledley, Fred D. (1994) "Non-viral gene therapy" Current Opinion in Biotechnology 5:626-636.
Schreier, Hans, Michael Ausborn, Susanne Gunther, Volkmar Weissig, Ramesh Chander (1995) "(Patho)physiologic Pathways to Drug Targeting: Artificial Viral Envelopes" J. Molecular Recognition 8:59-62.
Kabanov, A.V. and V.A. Kabanov (1995) "DNA Complexes with Polycations for the Delivery of Genetic Material into Cells" Bioconjugate Chem. 6(1):7-20.
Ledley, Fred D. (1995) "Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products" Human Gene Therapy 6:1129-1144.
Dunn, Philip M. (1994) "Dequalinium, a selective blocker of the slow afterhyperpolarization in rat sympathetic neurones in culture" European Journal of Pharmacology 252:189-194.
Steichen, John D., Michael J. Weiss, David R. Elmaleh, Robert L. Martuza (1991) "Enhanced in vitro uptake and retention of .sup.3 H-tetraphenylphosphonium by nervous system tumor cell" J. Neurosurg 74:116-122.
Christman, J. Eric, David S. Miller, Peter Coward, Lloyd H. Smith, Nelson N.H. Teng (1990) "Study of the Selective Cytotoxic Properties of Cationic, Lipophilic Mitochondrial-Specific Compounds in Gynecologic Malignancies" Gynecologic Oncology 39:72-79.
Neumann, E., M. Schaefer-Ridder, Y. Wang, P.H. Hofschneider (1982) "Gene transfer into mouse lyoma cells by electroporation in high electric fields" The EMBO Journal 1(7):841-845.
Hughes Jeffrey Allen
Lasch Jurgen
Rowe Thomas Cardon
Weissig Volkmar
Nguyen Dave Trong
Priebe Scott D.
University of Florida
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