Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-10-08
2008-11-25
Harris, Alana M. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S001110, C536S018700, C536S023100, C536S024300, C536S024310, C536S024500
Reexamination Certificate
active
07456268
ABSTRACT:
Isolated or purified oligonucleotides and isolated or purified morpholino oligomers; a method of detecting cancer or a predisposition to cancer in a mammal, comprising comparing the level of expression of Wip1 in the mammal to a control; a method of treating cancer in a mammal that expresses the same or a higher level of Wip1 as compared to a mammal of the same species that does not have cancer, comprising administering to the mammal a cancer-treating effective amount of a Wip1 inhibitor; a method of screening an oligonucleotide or morpholino oligomer for the ability to inhibit the expression of Wip1; a method of determining the efficacy with which a test oligonucleotide or morpholino oligomer inhibits Wip1 expression; a method of screening a compound for Wip1-inhibiting activity; and a method of determining the efficacy with which a test compound inhibits Wip1.
REFERENCES:
patent: 5965362 (1999-10-01), Pinkel et al.
patent: 6812339 (2004-11-01), Venter et al.
patent: 2003/0032027 (2003-02-01), Li et al.
patent: 2004/0167189 (2004-08-01), Bulavin et al.
patent: WO 01/55450 (2001-08-01), None
patent: WO 03/035843 (2003-05-01), None
patent: WO 03/083103 (2003-10-01), None
Amino acid databases. Dequence alignment between Applicants' Seq Id No. 1 and sequence 2226 from U.S. Patent 6,812,339 (filed Sep. 10, 2001).
Amino acid databases. Sequence alignment between Applicants' Seq Id No. 1 and Fiscella et al. (1997) and corresponding Accession No. U78305.
Belton,Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science, 74(14): 185-192 (1974).
Bulavin et al.,EMBO Journal, 18(23): 6845-6854 (1999).
Bulavin et al.,Nature, 411: 102-107 (2001).
Bulavin et al.,Nature Genetic, 36(4): 343-350 (2004).
Choi et al.,Genomics, 64: 298-306 (2000).
Fiscella et al.,Proc. Natl. Acad. Sci., 94: 6048-6053 (1997).
GenCore database Accession No. HSU78305, sequence alignment between Applicants' Seq Id No. 1, Seq Id No. 2 and nucleic acid database.
Kanai et al.,J. Cancer Res. Clin. Oncol., 127: 697-706 (2001).
Li et al.,Nature Genetics, 31: 133-134 (Jun. 2002).
Takekawa et al.,EMBO Journal., 19(23): 6517-6526 (2000).
Zee-Cheng et al.,Journal of Medicinal Chemistry, 13(2): 264-268 (1970).
Appella Ettore
Bulavin Dmitry
Fornace, Jr. Albert J.
Kallioniemi Anne
Harris Alana M.
Leydig , Voit & Mayer, Ltd.
The United States of America as represented by the Department of
LandOfFree
Materials and methods for inhibiting Wip1 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Materials and methods for inhibiting Wip1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Materials and methods for inhibiting Wip1 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4041167