Materials and methods for herpes simplex virus vaccination

Details Materials and methods for herpes simplex virus vaccination Materials and methods for herpes simplex virus vaccination

1983-02-04

1988-08-09

Kepplinger, Esther M.

Drug, bio-affecting and body treating compositions

Lymphokine

530395, 530806, A61K 39245

Patent

active

047627085

ABSTRACT:
Disclosed are immunologically active preparations of Herpes simplex virus envelope glycoproteins, gD-1 and gD-2. Preferably purified through use of a monoclonal anti-gD antibody immunoadsorbent, gD-1 and gD-2 preparations are incorporated in vaccines useful in generating immunological responses protective against Herpes simplex disease states. Disclosed also is the preparation and use in vaccination procedures of synthetic polypeptides comprising amino acid sequences which are: (1) substantially common to both gD-1 and gD-2; cumulatively hydrophilic in nature; and (3) specifically immunoreactive with a type common, monoclonal anti-gD antibody of Group VII classification.

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Slichtova et al., Arch. Virol., 66:207-214 (1980).
Norrild, "Immunochemistry of Herpes Simplex Virus Glycoproteins" in Current Topics in Microbiology and Immunology, 90:67-106, Springer Verlag, Berlin (1980).
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Killington et al., J. Virol. Meth., 2:223-236 (1981).
Eisenberg et al., J. Virology, 35:428-435 (1980).
Pereira et al., Infection and Immunity, 29:724-732 (1980).
Dix et al., Infection and Immunity, 34:192-199 (1981).
Skinner et al., Med. Microbiol. Immunol., 169:39-51 (1980).

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