Materials and methods for gene transfer

Details Materials and methods for gene transfer Materials and methods for gene transfer

1997-12-11

2000-10-10

Weber, Jon P.

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

435456, 435458, 435325, C12N 1587, C12N 1586, C12N 1588, C12N 500

Patent

active

061300896

ABSTRACT:
The subject invention provides methods for improving the efficiency of gene transfer to a target cell. The methods are particularly advantageous in that they facilitate the transduction of quiescent cells. In a preferred embodiment the efficiency of gene transfer using a viral vector is enhanced by transiently loading the dytosol of the target cell with dNTP and by transiently adding viral receptors to the surface of the target cell.

REFERENCES:
patent: 5512295 (1996-04-01), Kornberg et al.
Gao et al. Proc. natl. Acad. Sci. USA (1993) 90: 8925-8. Oct. 1993.
Meyerhans et al. J. Virology, (1994) 68(1):535-40. Jan. 1994.

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