Materials and methods for efficient lactic acid production

Details Materials and methods for efficient lactic acid production Materials and methods for efficient lactic acid production

2006-08-08

2009-12-08

Wehbe, Anne Marie (Department: 1633)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S139000

Reexamination Certificate

active

07629162

ABSTRACT:
The present invention provides derivatives of ethanologenicEscherichia coliK011 constructed for the production of lactic acid. The transformedE. coliof the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformedE. coliare useful for providing an increased supply of lactic acid for use in food and industrial applications.

REFERENCES:
patent: 5821093 (1998-10-01), Ingram et al.
patent: 2004/0152159 (2004-08-01), Causey et al.
patent: 2009/0148914 (2009-06-01), Causey et al.
Totemeyer et al, Mol. Microbiol. 27(3):553-562, 1998.
Weber et al, Microbiol. 151 (Pt. 3):707-716, 2005.
Zhu et al, Metabolic Eng. 3:218-225, 2001.
Chang, D. -E. et al. “Homofermentative Production of D- or L- Lactate in Metabolically EngineeredEscherichia coliRR1”Applied and Environmental Microbiology, Apr. 1999, pp. 1384-1389, vol. 65, No. 4.
Zhou, S. et al. “Production of Optically Pure D-Lactic Acid in Mineral Salts Medium by Metabolically EngineeredEscherichia coliW3110”Applied and Environmental Microbiology, Jan. 2003, pp. 399-407, vol. 69, No. 1.
Dien, B. S. et al. “RecombinantEscherichia coliengineered for production of L- lactic acid from hexose and pentose sugars”Journal of Industrial Microbiology and Biotechnology, 2001, pp. 259-264, vol. 27.
Zhou, S. et al. “Fermentation of 10% (w/v) sugar to D(−)-lactate by engineeredEscherichia coliB”Biotechnology Letters, 2005, pp. 1891-1896, vol. 27.
Zhou, S. et al. “Fermentation of 12% (w/v) glucose to 1.2 M lactate byEscherichia colistrain SZ194 using mineral salts medium”Biotechnology Letters, 2006, pp. 663-670, vol. 28.
Grabar, T. B. et al. “Methylglyoxal bypass identified as source of chiral contamination in L(+) and D(−)-lactate fermentations by recombinantEscherichia coli” Biotechnology Letters, 2006, pp. 1527-1535, vol. 28.
Zhou, S. et al. “Betaine tripled the volumetric productivity of D(−)-lactate byEscherichia colistrain SZ132 in mineral salts medium”Biotechnology Letters, 2006, pp. 671-676, vol. 28.

Affiliated with

Also associated with

Rating

Materials and methods for efficient lactic acid production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Materials and methods for efficient lactic acid production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Materials and methods for efficient lactic acid production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4119646