Chemistry: molecular biology and microbiology – Vector – per se
Patent
1998-05-29
2000-10-03
Hauda, Karen
Chemistry: molecular biology and microbiology
Vector, per se
435325, 424 931, 514 44, C12N 510, C12N 701, C12N 1500, A61K 4800
Patent
active
061271721
ABSTRACT:
The subject invention pertains to recombinant entomopox vectors which are useful for the delivery and stable expression of heterologous DNA in vertebrate cells. Specifically exemplified is a recombinant EPV from amsacta moorei (AmEPV). Because of the capacity of the EPV to incorporate foreign or heterologous DNA sequences, the vectors of the subject invention can be used to deliver DNA inserts that are larger than 10 kb in size. Accordingly, one aspect of the present invention concerns use of the recombinant vectors for delivery and expression of biological useful proteins in gene therapy protocols.
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Li Yi
Moyer Richard W.
Beckerleg Anne Marie S.
Hauda Karen
University of Florida
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