Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-08-23
2005-08-23
Wehbé, Anne Marie S. (Department: 1632)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C435S455000, C424S093200, C536S023100
Reexamination Certificate
active
06933145
ABSTRACT:
The subject invention pertains to recombinant entomopox vectors which are useful for the delivery and stable expression of heterologous DNA in vertebrate cells. Specifically exemplified is a recombinant EPV fromamsacta moorei(AmEPV). Because of the capacity of the EPV to incorporate foreign or heterologous DNA sequences, the vectors of the subject invention can be used to deliver DNA inserts that are larger than 10 kb in size. Accordingly, one aspect of the present invention concerns use of the recombinant vectors for delivery and expression of biological useful proteins in gene therapy protocols. In addition, the subject invention concerns novel AmEVP polypeptides and the polynucleotide sequences which encode these polypeptides.
REFERENCES:
patent: 5721352 (1998-02-01), Moyer et al.
patent: 5753258 (1998-05-01), Schreier et al.
patent: 5762924 (1998-06-01), Dall et al.
patent: 5935777 (1999-08-01), Moyer et al.
patent: 6106825 (2000-08-01), Moyer et al.
patent: 6127172 (2000-10-01), Moyer et al.
patent: 9413812 (1994-06-01), None
patent: WO 96/09074 (1996-03-01), None
patent: 9850571 (1998-11-01), None
patent: WO 99/61069 (1999-12-01), None
Marshall; Gene Therapy's Growing Pains, 1995, Science, vol. 269: 1050-1055.
Orkin et al.; Report AMD Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, 1995.
Afonso, C.L., E.R. Tulman, Z. Lu, E. Oma, G.F. Kutish, and D.L. Rock [1999] “The genome ofMelanoplus sanguinipesEntomopoxvirus”J. Virol.73:533-552.
Arif, B. M. and Kurstak. E. [1991]. The Entomopoxviruses. In “Viruses of Invertebrates,” E. Kurstak, Ed., pp. 179-195, Marcel Dekker, Inc., New York.
Bawden, A. L., Li, Y., Glassberg, K., and Moyer, R. W. [2000] Entomopoxvirus Vectors. In “Viral Vectors: Basic Science and Gene Therapy,” p. 341-355, A. Cid-Arregui, Ed., Eaton Publishing, Natick, MA (In Press).
Bawden, Alison L., Kathryn J. Glassberg, James Diggans et al. (2000) “Complete Genomic Sequence of theAmsacta mooreiEntomopoxvius: Analysis and Comparison with Other Poxviruses”Virology274:120-139.
Berns, Kenneth I. and Roy A. Bohenzky (1987) “Adeno-Associated Viruses: An Update” Adv. Virus Res. 32:243-306.
Fernon, C.A., A.P. Vera, R. Crnov, J. Lai-Fook, R.J. Osborne, and D.J. Dall [1995] “Replication ofHeliothis armigeraentomopoxvirus in vitro”J Invertebr. Pathol.66:216-223.
Gauthier, Laurent Francois Cousserans, Jean Claude Veyrunes, Max Bergoin (1995) “TheMelolontha melolonthaEntomopoxvirus (MmEPV) Fusolin Is Related To The Fusolins Of Lepidopteran EPVs And To The 37K Baculovirus Glycoprotein” Virology 208:427-436.
Goebel, S. J., Johnson, G. P., Perkus, M. E., Davis, S. W., Winslow, J. P., and Paoletti, E. [1990] “The complete DNA sequence of vaccinia virus”Virology179, 247-66, 517-63.
Gooding, L. R. [1992] “Virus proteins that counteract host immune defenses”Cell71:5-7.
Goodwin, R. H., J. R. Adams and M. Shapiro [1990] “Replication of the entomopoxvirus fromAmsacta mooreiin serum-free cultures of a gypsy moth cell line”J. Invertebr. Pathol.56:190-205.
Granados, R.R. (1981) Entomopoxvirus infections in insects, In: Pathogenesis of invertebrate Microbial Disease, pp 102-126, Davidson, E.W. (ed.) New Jersey, Allanheld Totowa.
Gruidl, M. E., Hall, R. L., and Moyer, R. W. [1992] “Mapping and molecular characterization of a functional thymidine kinase fromAmsacta mooreientomopoxvirus”Virology186:507-516.
Hall, R. L. and Hink, W. F. [1990] “Physical mapping and field inversion gel electrophoresis ofAmsacta mooreientomopoxvirus DNA”Arch. Virol.110:77-90.
Hall, R.L. and R.W. Moyer [1991] “Identification, cloning, and sequencing of a fragment ofAmsacta mooreientomopoxvirus DNA containing the spheroidin gene and three vaccinia virus-related open reading frames”J. Virol.65:6516-6527.
Hall, R. L. and Moyer, R. W. [1993] “Identification of anAmsactaspheroidin-like protein within the occlusion bodies ofChoristoneuraentomopoxviruses”Virology192:179-187.
Hall, R. L., Li, Y., Feller, J. A., and Moyer, R. W. [1996] “TheAmsacta mooreientomopoxvirus spheroidin gene is improperly transcribed in vertebrate poxviruses”Virology224:427-436.
Kaplitt, Michael G., Paola Leone, Richard J. Samulski, Xiao Xiao, Donald W. Pfaff, Karen L. O'Malley, Matthew J. During (1994) “Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain” Nat. Genet 8:148-154.
Kotin, Robert M., R. Michael Linden, Kenneth I. Berns (1992) “Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination” The EMBO Journal 11(13):5071-5078.
Langridge, W.H.R. (1983) “Detection ofAmsacta mooreiEntomopoxvirus and Vaccinia Virus Proteins in Cell Cultures Restrictive for Poxvirus Multiplication” Journal of Invertebrate Pathology 42:77-82.
Li, X., Barrett, J. W., Yuen, L., and Arif. B. M. [1997] “Cloning, sequencing and transcriptional analysis of the Choristoneura fumiferana entompoxvirus spheroidin gene”Virus Res.47:143-154.
Li, Yi, Richard L. Hall, Richard W. Moyer (Dec. 1997) “Transient, Nonlethal Expression of Genes in Vertebrate Cells by Recombinant Entomopoxviruses” Journal of Virology 71(12):9557-9562.
Li, Y., R.L. Hall, S.L. Yuan, R.W. Moyer (1998) “High-level expression ofAmsacta mooreientomopoxvirus spheroidin depends on sequences within the gene” Journal of General Virology 79:613-622.
Lytvyn, V., Y. Fortin, M. Banville, B. Arif, and C. Richardson [1992] “Comparison of the thymidine kinase genes from three entomopoxviruses”J. Gen. Virol.73:3235-3240.
Moyer, R. W. [1994] Entomopoxviruses, p. 392-397,Encyclopedia of Virology, R.G. Webster and A. Granoff (eds.), Academic Press Ltd., London).
Nienhuis, Arthur W., Christopher Edward Walsh, Johnson Liu (1993) “Viruses as Therapeutic Gene Transfer Vectors”, In: N.S. Young (ed.) Viruses and Bone Marrow, Marcel Decker, New York, pp. 353-414.
Palmer, Christopher, Davin P. Miller, Susan A. Marlow et al. (1995) “Genetic modification of an entomopoxvirus: delection of the spheroidin gene does not affect virus replication in vitro”Journal of General Virology76:15-23.
Ross, Gail, Robert Erickson, Debra Knorr, et al. (Sep. 1996) “Gene Therapy in the United States: A Five-Year Status Report”Human Gene Therapy7:1781-1790.
Smith, G. L., Chan. Y. S. and Howard, S. T. [1991] “Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat”J. Gen. Virol.72:1349-1376.
Smith, G. L. [2000] “Secreted poxvirus proteins that interact with the immune system”Effects of Microbes on the Immune System491-507).
Sriskantha, A., Osborne, R. J., and Dall, D. J. [1997]0 “Mapping of the Heliothis armigera entomopoxvirus (HaEPV) genome, and analysis of genes encoding the HaEPV spheroidin and nucleoside triphosphate phosphohydrolase I proteins”J Gen Virol78:3115-3123.
Verma, Inder M. and Nikunj Somia (1997) “Gene Therapy—promises, problems and prospects”Nature389:239-242.
Winter, J., R.L. Hall, and R.W. Moyer [1995] “The effect of inhibitors on the growth of the entomopoxvirus fromAmsacta mooreiinLymantria dispar(gypsy moth) cells”Virology211:462-473.
Geoffrey L. Smith (Mar. 1994) “Virus strategies for evasion of the host response to infection”Trends in Microbiology2(3):81-88.
Mustafa, Amir and Leonard Yuen (1991) “Identification and sequencing of theChoristoneura biennisentomopoxvirus DNA polymerase gene”J. DNA Sequencing and Mapping2:39-45.
Li Yi
Moyer Richard W.
S. Wehbé Anne Marie
Saliwanchik Lloyd & Saliwanchik
University of Florida Research Foundation Inc.
LandOfFree
Materials and methods for delivery and expression of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Materials and methods for delivery and expression of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Materials and methods for delivery and expression of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3462873