Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-05-30
1999-06-29
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
523115, 623 16, A61F 228
Patent
active
059165855
ABSTRACT:
The present invention is directed to hydrophobic biodegradable polymeric materials having at least one surface thereof rendered more hydrophilic by attachment of at least one layer of a hydrophilic polymer thereto. The hydrophilic polymer layer is cross-linked together on the surface of the biodegradable material with a cross-linking agent or scheme that is biodegradable. Bioactive species are immobilized to chemically functional groups of the components of the first layer or to unreacted chemically functional groups of the cross-linking agent. Optionally, the bioactive species may be reversibly immobilized through chemically functional linkages that are degradable. The result is an implantable construction with immobilized bioactive species having structural components that are all subject to degradation in the body of a recipient.
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Cook Alonzo D.
Drumheller Paul D.
Azpuru Carlos
Gore Enterprise Holdings Inc.
Sheets Eric J
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