Material for buffered resorbable internal fixation devices and m

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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Details

5147721, 5147723, 5147724, A61F 202, A61K 4730, A61K 4732

Patent

active

058173285

ABSTRACT:
A bioerodible implantable material, comprising a bioerodible polymer that produces acidic products upon hydrolytic degradation, and a buffering compound that buffers the acidic products and maintains the local pH within a desired range. The buffer compound acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Materials made according to the invention may be used for internal fixation devices (IFDs) for bone repair.

REFERENCES:
patent: 4637931 (1987-01-01), Schmitz
patent: 4780319 (1988-10-01), Zentner et al.
patent: 5336505 (1994-08-01), Ng et al.
patent: 5397572 (1995-03-01), Combes et al.
patent: 5502092 (1996-03-01), Barrows et al.

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