Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1996-04-03
1998-10-06
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
5147721, 5147723, 5147724, A61F 202, A61K 4730, A61K 4732
Patent
active
058173285
ABSTRACT:
A bioerodible implantable material, comprising a bioerodible polymer that produces acidic products upon hydrolytic degradation, and a buffering compound that buffers the acidic products and maintains the local pH within a desired range. The buffer compound acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Materials made according to the invention may be used for internal fixation devices (IFDs) for bone repair.
REFERENCES:
patent: 4637931 (1987-01-01), Schmitz
patent: 4780319 (1988-10-01), Zentner et al.
patent: 5336505 (1994-08-01), Ng et al.
patent: 5397572 (1995-03-01), Combes et al.
patent: 5502092 (1996-03-01), Barrows et al.
Gresser Joseph D.
Klibanov Alexander M.
Langer Robert
Trantolo Debra J.
Wise Donald L.
Azpuru Carlos
Cambridge Scientific, Inc.
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