Material able to fix reversibly biologial macromolecules, its pr

Details Material able to fix reversibly biologial macromolecules, its pr Material able to fix reversibly biologial macromolecules, its pr

1978-09-19

1981-12-29

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Processes of making, purifying or recovering

424 12, 424 87, 424 88, 424 92, A61K 3704, A61K 3900, A61K 3912, A61K 39106

Patent

active

043082548

ABSTRACT:
A process for preparing a porous solid material for use in a chromatography column and which is capable of fixing reversibly biological macromolecules comprises coating a porous inorganic support with a polysaccharide polymer having .alpha.-glycol groups which undergo oxidative scission, subjecting the polysaccharide polymer to an oxidative scission reaction, reacting the resulting oxidized polysaccharide polymer with an amino molecule or macromolecule having the formula R'--NH.sub.2 to produce a polysacchride polymer having the formula R.sub.4 --CH.dbd.N--R' and reducing the imine bond in said immediately above defined polysaccharide polymer to a stable amine bond.

REFERENCES:
patent: 3694163 (1972-09-01), Sherelis
patent: 3959079 (1976-05-01), Mareschi et al.
patent: 3959080 (1976-05-01), Orth et al.
patent: 3963441 (1976-06-01), Dietrich
patent: 3983053 (1976-09-01), Courtney et al.
patent: 4039652 (1977-08-01), Adams et al.
patent: 4059685 (1977-11-01), Johnson
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patent: 4081244 (1978-03-01), Polito et al.
patent: 4081245 (1978-03-01), Polito
patent: 4081329 (1978-03-01), Jaworek et al.
patent: 4125492 (1978-11-01), Cuatrecasas et al.
patent: 4141857 (1979-02-01), Levy
Chemical Abstracts, vol. 86 (1977), p. 135338n.
Chemical Abstracts, vol. 82 (1975), p. 40435w.

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