Material

Details Material Material

2000-11-27

2004-02-03

Barts, Samuel (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S123100, C536S053000, C536S120000, C514S002600

Reexamination Certificate

active

06686457

ABSTRACT:

MATERIAL
A material containing so-called matrix to which saccharide has been bound via a spacer is described below.
The active part of the material consists of either:
1. Blood group A—O(CH
2
)
n
PhNH—CO—(CH
2
)
m
NH—CH
2
—CH(OH)—CH
2
—O-Matrix
or:
2. Blood group B—O(CH
2
)
n
PhNH—CO—(CH
2
)
m
NH—CH
2
—CH(OH)—CH
2
—O-Matrix
where Matrix denotes e.g. specifically, cross-linked agarose, especially of the type Sepharose® Fast Flow, where —O(CH
2
)
n
PhNH—CO—(CH
2
)
m
NH—CH
2
—CH(OH)—CH
2
— consists of spacer to separate the blood group determinant from the Matrix, where n and m, respectively, is an integer, n is for example one of 0, 1, 2, 3 or 4, and m is for example 1, 2, 3, 4, 5, 6 or 7, and where the linkage between —O— and Matrix is to a carbon atom in the Matrix.
Blood group A—O(CH
2
)
n
PhNH—CO—(CH
2
)
m
NH— and
Blood group B—O(CH
2
)
n
PhNH—CO—(CH
2
)
m
NH—, respectively, is below called (the) ligand.


REFERENCES:
patent: 4238473 (1980-12-01), Lemieux et al.
patent: 5962422 (1999-10-01), Bertozzi et al.

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