Matansinol 3-n-hexadecanoate

Details Matansinol 3-n-hexadecanoate Matansinol 3-n-hexadecanoate

1979-03-19

1981-05-05

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424854, C07D49818

Patent

active

042658144

ABSTRACT:
Maytansinoids of the formula: ##STR1## wherein R is hydrogen or alkyl of 1 to 15 carbon atoms are produced by contacting, in the presence of a carbodiimide, maytansinol with a carboxylic acid of the formula:

REFERENCES:
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4151042 (1979-04-01), Higashide et al.
patent: 4162940 (1979-07-01), Higashide et al.
Kupchan et al., "J. Med. Chem.", vol. 21, No. 1, pp. 31-37, (1978).

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