Mast cell-specific signal transducer and cDNA thereof

Details Mast cell-specific signal transducer and cDNA thereof Mast cell-specific signal transducer and cDNA thereof

2007-06-05

2007-06-05

Carlson, Karen Cochrane (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069100

Reexamination Certificate

active

11529217

ABSTRACT:
The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression vector involving these polynucleotides, transformed cells induced by these expression vectors, and antibodies against the foregoing proteins. The signal transducer provided in the present invention is useful for screening of novel medicines against allergic diseases.

REFERENCES:
patent: 6831151 (2004-12-01), Goitsuka
Goitsuka et al.,International Immunology, vol. 12, No. 4, pp. 573-580, 2000.
Goitsuka et al.,Igaku no Ayumi, vol. 192, No. 10, pp. 1027-1031, 2000.
Cao et al.,J. Exp. Med., vol. 190, No. 10, pp. 1527-1534, 1999.
Goitsuka et al.,J. Immunol., vol. 161, pp. 5804-5808, 1998.
Jackman et al.,J. Biol. Chem., vol. 270, No. 13, pp. 7029-7032, 1995.

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