Mast cell protease that cleaves fibrinogen

Details Mast cell protease that cleaves fibrinogen Mast cell protease that cleaves fibrinogen

1997-11-25

1999-10-19

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435226, 4352523, 4353201, 530413, 536 234, C12N 1562, C12N 964, C12N 1567, C12N 1585

Patent

active

059687827

ABSTRACT:
Compositions containing a Trypson-like serine protease from mast cells ("tryptase-7") are provided. The compositions are useful for treating blood clot formation in vitro and in in vitro. Also provided is a novel bioengineering method to produce the tryptase-7 and other serine proteases in active form and in large quantities.

REFERENCES:
patent: 5087564 (1992-02-01), Mai et al.
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5202239 (1993-04-01), Tarnowski et al.
patent: 5239058 (1993-08-01), Vlasuk et al.
patent: 5372812 (1994-12-01), Reed et al.
patent: 5385732 (1995-01-01), Anderson et al.
patent: 5405771 (1995-04-01), Anderson et al.
patent: 5525623 (1996-06-01), Spear et al.
patent: 5538863 (1996-07-01), Price
patent: 5541087 (1996-07-01), Lo et al.
patent: 5567602 (1996-10-01), Clark et al.
Wang, Z.-M., et al., Biological Chemistry Hoppe-Seyler, vol. 376, "Production of active recombinant human chymase from a construct containing the enterokinase cleavage site of trypsinogen in place of the native propeptide sequence", pp. 681-684, 1995.
Ghildyal, N., et al., "Fate of Two Mast Cell Tryptases . . . ", J. Exp. Med., (1996), 184:1061-1073.
Matsumoto, R., et al., "Packaging of Proteases . . . ". J. Biol. Chem., (1995), 270:33:19524-19531.
Braganza, V., et al., "Tryptase from Rat Skin: . . . ", Biochemistry, (1991), 30:4997-5007.
Schwartz, L., "Tryptase, a mediator of . . . ", J Allergy Clin Immunol, (1990), 86:4 Pt2:594-598, Abstract.
Alter, S., et al., "Interactions of human mast cell . . . ", Arch Biochem Biophys, (1990), 276:1:26-31, Abstract.
Harvima, I., et al., "Effect of human mast . . . ", Int Arch Allergy Appl Immunol, (1989), 90:1:104-108, Abstract.
Katumuma, N., et al., "Biological functions . . . ", J Cell Biochem, (1988), 38:4:291-301 Abstract.
Schwartz, L., et al., "The fibrinogenolytic activity . . . ", J Immunol, (1985), 135:4:2762-2767 Abstract.
Seppa, H., et al., "The role of chrymotrypsin-like . . . ", Inflammation, (1980), 4:1:1-8 Abstract.
Pastan, I., et al., "Purification and properties . . . ", J Biol Chem, (1996), 241:21:5090-5094 Abstract.
Schwartz, L., et al., "Effect of Tryptase . . . ", J Allergy Clin Immunol, (1985), 75 (1 Part 2) Abstract.
Forsberg, G., et al., "An evaluation of . . . ", J Protein Chem, (1992), 11:2:201-211 Abstract.
Light, A., et al., "The amino-terminal . . . ", J. Protien Chem, (1991), 10:5:475-480 Abstract.
Martinez, A., et al., "Expression of recombinant . . . ", Biochem J., (1995), 306(Pt 2): 589-597 Abstract.
Su, X., et al., "Production of recombinant . . . ", Biotechniques, (1992), 12:5:756-762 Abstract.
Kuhn, S., et al., "The baculovirus expression . . . ", Gene, (1995), 162:2:225-229 Abstract.
Kroll, D., et al., "A multifunctional prokaryotic . . . ", DNA Cell Biol, 12:5:441-453 Abstract 1993.
Dobrynin, V., et al., "Chemical-enzymatic . . . ", Bioorg Khim, (1989), 15:9:1232-1238 Abstract.
Scheele, G., et al., "Proteolytic processing . . . ", J Biol Chem, 258:3:2005-2009 Abstract.
Bajusz, S., Peptide Inhibitors of Trypsin-Like Enzymes, Symposia Biologica Hungarica 25; pp. 279-298, (1984).
Jouko Lohi et al., Pericellular Substrates of Human Mast Cell Tryptase: 72,000 Dalton Gelatinase and Fibronectin, Journal of Cellular Biochem., 50;337-349 (1992).
Beat Steiner et al., Peptides Derived from a Sequence within .beta..sub.3 Integrin Bind to Platelet .alpha..sub.IIb .beta..sub.-- (GPIIIb-IIIa) and Inhibit Ligand Binding, J. of Biological Chem. 268, No. 10, Apr. 5, 1993, pp. 6870-6873.
Rami Herskoviz et al., Nonpeptidic Analogues of the Arg-Gly-Asp (RGD) Sequence Specifically Inhibit the Adhesion of Human Tenon's Capsule Fibroblasts to Fibronectin, Investigative Opthalmology & Visual Science, vol. 35, No. 5, Apr. 1994, pp. 2585-2591.
Clark, J., et al., Tryptase Inhibitors Block Allergen-induced Airway and Inflammatory Responses in Allergic Sheep, Am J Respir Crit Care Med (1995) 152;2076-2083.
McNeil et al., Isolation, characterization, and transcription of the gene encoding mouse mast cell protease protease 7,Proc. Natl. Acad. Sci. USA 89:11174-11178, 1992.
Gruber, B., et al., "The Mast Cell as an Effector of Connective Tissue Degradation: A Study of Matrix Susceptibility to Human Mast Cells",Biochem & Biophys Res Com, (1990), 171;3;1272-1278.
Cairns, J., et al., "Mast Cell Tryptase Is a Mitogen for Epithelial Cells",J Immun, (1996), 156;275-283.
Kielty, C., et al., "Catabolism of Intact Type VI Collagen Microfibrils: Susceptibility To Degradation By Serine Proteinases", Biochem & Biophys Res Com. (1993), 191;3;1230-1236.
Kovanen, P., et al., "Infiltrates of Activated Mast Cells at the Site of Coronary Atheromatous Erosion or Rupture in Myocardial Infarction", Circulation, (1995), 92;5;1084-1088.
Saarinen, J., et al., "Activation of Human Interstitial Procollagenase through Direct Cleavage of the Leu.sup.83 -Thr.sup.84 Bond by Mast Cell Chymase",J Bio Chem, (1994), 269;27;18134-18140.
DuBuske, L., et al., "Granule-Associated Serine Neutral Proteases of the Mouse Bone Marrow-Derived Mast Cell That Degrade Fibronectin: Their Increase After Sodium Butyrate Treatment of the Cells", J Immun. , (1984), 133;3;1535-1541.
Constantinides, P., et al., Infiltrates of Activated Mast Cellsa t the site of Coronary Atheromatous Erosion or Rupture in Myocardial Infarction, Circulation (1995) 92;1083.

Affiliated with

Also associated with

Rating

Mast cell protease that cleaves fibrinogen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mast cell protease that cleaves fibrinogen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mast cell protease that cleaves fibrinogen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2054699