Massive parallel method for decoding DNA and RNA

Details Massive parallel method for decoding DNA and RNA Massive parallel method for decoding DNA and RNA

2007-08-20

2009-12-22

Riley, Jezia (Department: 1637)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S006120, C435S091200, C536S023100, C536S024300, C536S025300, C536S026600

Reexamination Certificate

active

07635578

ABSTRACT:
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.

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