Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2008-02-28
2009-12-01
Souw, Bernard E (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000, C250S282000, C436S056000, C436S089000, C530S350000, C435S006120, C702S027000
Reexamination Certificate
active
07626162
ABSTRACT:
When a liquid mixture of two samples such as biological samples labeled with stable isotopes is subjected to a relative quantitative analysis using a liquid chromatography-tandem mass spectrometry system, various constituents are simultaneously ionized. Accordingly, sufficient time required for second mass spectrometry is not ensured, whereby some ions remain unanalyzed after measurement. To address this problem, after second mass spectrometry, amino acid sequencing is performed using the analysis data of the second mass spectrometry, which enables determination on the presence/absence of a specific amino acid labeled with a stable isotope. When the specific amino acid is present, the m/z value of an isotopically-labeled-paired ion in an MS spectrum is calculated, and non-target information for use in second mass spectrometry is created using the calculated m/z information. This avoids redundant second mass spectrometry on sample components derived from the same peptide while allowing second mass spectrometry to be efficiently performed.
REFERENCES:
patent: 6355416 (2002-03-01), Abramson
patent: 6894276 (2005-05-01), Takada et al.
patent: 6917037 (2005-07-01), Ootake et al.
patent: 7180056 (2007-02-01), Ohtake et al.
patent: 2004/0248317 (2004-12-01), Swamy et al.
patent: 2006/0094121 (2006-05-01), Reid et al.
patent: 2006/0134723 (2006-06-01), Fischer
patent: 2006/0289735 (2006-12-01), Ohtake et al.
patent: 2008/0283740 (2008-11-01), Hashiba et al.
patent: 2009/0053817 (2009-02-01), Reid et al.
patent: 2005-345332 (2005-12-01), None
patent: 2006-53004 (2006-02-01), None
patent: 3766391 (2006-02-01), None
patent: 2006-329881 (2006-12-01), None
patent: WO 02/25265 (2002-03-01), None
Hashiba Shuhei
Sakamoto Takeshi
Antonelli, Terry Stout & Kraus, LLP.
Hitachi , Ltd.
Souw Bernard E
LandOfFree
Mass spectrometry system and mass spectrometry method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mass spectrometry system and mass spectrometry method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mass spectrometry system and mass spectrometry method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4125776