Mass spectrometry assay for plasma-renin

Radiant energy – Ionic separation or analysis – Methods

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C250S281000, C250S288000, C250S42300F, C250S424000

Reexamination Certificate

active

07834313

ABSTRACT:
Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample.

REFERENCES:
patent: 3984532 (1976-10-01), De Castro
patent: 4022577 (1977-05-01), Brooker et al.
patent: 4112064 (1978-09-01), Farrenkopf et al.
patent: 5572025 (1996-11-01), Cotter et al.
patent: 5869832 (1999-02-01), Wang et al.
patent: 6107623 (2000-08-01), Bateman et al.
patent: 6107626 (2000-08-01), Wang et al.
patent: 6124137 (2000-09-01), Hutchens et al.
patent: 6204500 (2001-03-01), Whitehouse et al.
patent: 6268144 (2001-07-01), Koster
patent: 7332296 (2008-02-01), Elased et al.
patent: 2008/0166697 (2008-07-01), Caulfield et al.
patent: 2009/0314936 (2009-12-01), Okuno
patent: WO 2005/083113 (2005-09-01), None
Cavalier et al, Analytical Veriation in Plasma Renin Activity: Implications for the Screening of Primary Aldosteronism, Clinical Chemistry, 53(4):803-804, 2007.
Derkx et al, More on Renin, Clin. Chem., 43(4):694-697, 1997.
Donoghue et al, A Novel Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensis 1-9, Circ. Res., 87:e1-e9, 2000.
Funder et al, Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Sociiety Clinical Practice Guideline, J Clin Endocrinol Metab, 93(9):3266-3281, 2008.
Fyhrquist et al, Radioimmunoassay of Plasma Renin Activity, Clin. Chem., 22(2):250-256, 1976.
Healy et al, Kidney Aminopeptidase A and Hypertension, Part I: Spontaneously Hypertensive Rats, Hypertension, 33:740-745, 1999.
Hermann et al, Measurement and Characterization of Angiotensin Peptides in Plasma, Clin. Chem., 34(6):1046-1051, 1988.
Kodish et al, Plasma renin concentration: comparision of angiotensianse inhibitors and correlation with plasma renin activity and aldosterone, JLCMAK 83(5):705-715, 1974.
Kurtz et al., Identification of Plasma Angiotensinase as Aminopeptidase, Nature, 221:92-93, 1969.
Nussberger et al, Specific Measurement of Angiotensin Metabolites and in Vitro Generated Angiotensin II in Plasma, Hypertension, 8:476-482, 1986.
Ryan et al, pH-Independent Inhibition of Plasma Angiotensis I Degradation: Implications for Renin Assay, Clinica Chimica Acta, 98:67-76, 1979.
Schwartz et al, Screening for Primary Aldosteronism in Essential Hypertension: Diagnostic Accuracy of the Ratio of Plasma Aldosterone Concentration to Plasma Renin Activity, Clin. Chem., 51(2):386-394, 2005.
Sealey et al, Plasma renin and aldosterone measurements in low renin hypertensive states, Trends in Endorinology and Metabolism, 16(3):86-91, 2005.
Sealey et al, Radioimmunoassay of Plasma Renin Activity, Seminars in Nuclear Medicine, 5(2):189-202, 1975.
Song et al, Kidney Aminopeptidase A and Hypertension, Part II: Effects of Angiotensin II, Hypertension, 33:746-752, 1999.
Tonna et al, Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis FSGS, Gene, Author Manuscript; available in PMC Jul. 6, 2009, 20 pgs.
Voelker et al, Improved HPLC-Radioimmunoassay for Quantifying Angiotensin II in Plasma, Clin. Chem. 40(8):1537-1543, 1994.
Walsh et al, Proteases in blood clotting, Essays in Biochemistry—Proteases in Biology and Medicine, 38:95-111, 2002.
Yi et al, Inhibition of Intrinsic Proteolytic Activities Moderates Preanalytical Variability and Instability of Human Plasma, Journal of Proteome Research, 6:1768-1781, 2007.
Yi et al, Intrinsic Peptidase Activity Causes a Sequential Multi-Step Reaction SMSR) in Digestion of Human Plasma Peptides, Journal of Proteome Research, 6:5112-5117, 2008.
Christie, Solid-phase extraction columns in lipid analysis. Lipid Technology, 3:31-33 (1991) and 16-19 (2003) located at http://www.lipidlibrary.co.uk/topics/solid—pe/index/htm.
Fredline et al. Measurement of Plasma Renin Activity with use of HPLC-electrospray-Tandem Mass Spectrometry,Clin. Chem.45:659-664 (1999).
Klickstein, L.B. and Wintroub, B.U., Separation of Angiotensins and Assay of Angiotensin-Generating Enzymes by High-Performance Liquid Chromatography,Anal Biochem120: 146-150 (1982).
Kohara et al., Reassessment of Plasma Angiotensins Measurement: Effects of Protease Inhibitors and Sample Handling Procedures,Peptides12:1135-1141 (1991).
Meng et al., Effects of Dietary Salt on Angiotensin Peptides in Kidney,J. Am. Soc. Nephrol.6:1209-1215 (1995).
Meng et al., Simplified method for quantitation of angiotensin peptides in tissue,J. Chromatogr.21, 614(1):19-25 (1993).
Merchant, M. and Weinberger, S.R., Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry,Electrophoresis21:1164-77 (2000).
Miyaszaki et al., Determination of Renin Activity in Human Plasma by Column-Switching High-Performance Liquid Chromatography with Fluorescence Detection,J Chromatogr.490: 43-51 (1989).
Mulder et al., Automated on-line solid-phase extraction coupled with HPLC for measurement of 5-Hydroxyindole-3-acetic acid in urine. Clinical Chemistry, 51:9, 1698-1703 (2005).
Robb et al., Atmospheric Pressure Photoionization: An Ionization Method for Liquid Chromatography-Mass Spectrometry.Anal. Chem.72(15):3653-3659 (2000).
Sealey, J.E., Plasma Renin Activity and Plasma Prorenin Assays,Clin. Chem., 37:1811-1819 (1991).
Sommer et al., Direct Measurement of Immunoreative Renin during Changes of Posture in Man, Horm Res. 37:171-175 (1992).
Ulmer and Meikle, Sample requirements for plasma rennin activity and immunoreactive rennin. Clinical Chemistry, 46(9): 1442-1444 (2000).
Wright et al., Proteinchip® surface enhanced laser desorption/ionization (SELDI) mass spectrometry: a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures,Prostate Cancer and Prostatic Diseases2:264-76 (1999).
Ye et al., Automated on-line custom-switching HPLC-MS/MS method with pea determination of nine environment phenols in urine. Anal. Chem. 77(16): 5407-5413, 2005.
Bean and Carr, Tandem Mass Spectrometry of Peptides Using Hybrid and Four-Sector Instruments: A Comparative Study, Anal. Chem. 63:1473-1481, 1991.
Ferranti et al, Study of interaction of styrene oxide with Angiotensin by mass spectrometry, Carcinogenesis, vol. 13, No. 8, pp. 1397-1401, 1992.
International Search Report dated Sep. 21, 2009 for PCT Application No. PCT/US2009/53189.
Tang et al, Fragmentation Reactions of Multiply-Protonated Peptides and Implications for Sequencing by Tandem Mass Spectrometry with Low-Energy Collision-Induced Dissociation, Anal. Chem. 65:2824-2834, 1993.
Shionoiri et al,, Measurement of plasma active rennin by solid phase radioimmunoassay using monoclonal antibodies. Am J Med Sci, 300(3): 138-143, 1990.
Shionoiri et al., Renin gene expression in the adrenal and kidney of patients with primary aldosteronism. Journal of Clinical Endocrinology and Metabolism, 74: 103-107, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Mass spectrometry assay for plasma-renin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mass spectrometry assay for plasma-renin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mass spectrometry assay for plasma-renin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4249920

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.