Mass spectrometric quantification of chemical mixture...

Details Mass spectrometric quantification of chemical mixture... Mass spectrometric quantification of chemical mixture...

2006-08-08

2006-08-08

Font, Frank G. (Department: 2883)

Radiant energy

Ionic separation or analysis

Methods

C250S281000

Reexamination Certificate

active

07087896

ABSTRACT:
Relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required. The methods are particularly useful for differential phenotyping in proteomics and metabolomics research, in which molecules varying in concentration across samples are identified. These identified species may serve as biological markers for disease or response to therapy.

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