Mass spectrometric methods for detecting mutations in a...

Details Mass spectrometric methods for detecting mutations in a... Mass spectrometric methods for detecting mutations in a...

2006-07-11

2006-07-11

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C436S094000

Reexamination Certificate

active

07074563

ABSTRACT:
Provided herein are mass spectrometric methods for detecting a mutation in a target nucleic acid. In an embodiment, provided is a method which comprises digesting a target nucleic acid molecule; capturing digested fragments on a solid support that comprises oligonucleotides complementary thereto; and detecting hybrids and the molecular weights of captured fragments by mass spectrometry, thereby identifying mutations in the target nucleic acid molecule.

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