Mass spectrometric immunoassay

Details Mass spectrometric immunoassay Mass spectrometric immunoassay

1973-06-21

1977-05-10

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 250282, 250303, 424 12, 424 15, G01N 3316, G21H 502, B01D 5944

Patent

active

040228762

ABSTRACT:
A method and means of making an immunological assay is provided whereby stable isotopes of certain elements, or long-lived radioisotopes of these elements are used to tag antigens or antibodies. A known amount of the tagged antibodies or antigens are then mixed with the unknown number of antigens or antibodies forming an antigen-antibody complex, (bound) and free tagged antigens, or antibodies, (unbound). The bound antigens or antibodies are separated from the unbound, and their quantity is determined by negative ion mass spectrometry. An aliquot of the unbound or bound antigens or antibodies is taken and dried in a metal crucible, for example, which is then inserted into a negative ion mass spectrometer where the sample is vaporized, ionized and the number of tagging atoms is then counted. From the information provided by the count, an immunoassay can be established.

REFERENCES:
patent: 3663684 (1972-05-01), Freedman et al.
patent: 3666854 (1972-05-01), Eisentraut
patent: 3697638 (1972-10-01), Hansen
patent: 3776698 (1973-12-01), Eisentraut
Radioimmunoassay Methods, ed Kirkham et al., 1970, pp. 405-412.

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