Mass spectrometers and methods for rapid screening of libraries

Details Mass spectrometers and methods for rapid screening of libraries Mass spectrometers and methods for rapid screening of libraries

1997-10-08

1999-09-28

Nguyen, Kiet T.

Radiant energy

Ionic separation or analysis

With sample supply means

H01J 4900

Patent

active

059592974

ABSTRACT:
Methods and apparatus for screening diverse arrays of materials are provided. Techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering and/or optimizing new materials with specific desired properties. A scanning mass spectrometer is used which includes an ionization chamber and a collector that outputs an electrical signal responsive to the quantity of gas ions contacting the collector surface. A conduit system selectively withdraws samples from the array of materials, passing the samples into the ionization chamber. In a specific embodiment, reactants are passed through the conduit system to the selected regions of interest on the substrate.

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Kelly, Michele, et al., "Characterization of SH2-Ligand Interactions via Library Affinity Selection with Mass Spectrometric Detection," Biochemistry, vol.35, No. 36, pp. 11747-11755 (1996).

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