Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2008-04-29
2008-04-29
Berman, Jack (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S281000
Reexamination Certificate
active
11018086
ABSTRACT:
A mass spectrometer and a method of mass spectrometry are disclosed wherein periodic background noise is effectively filtered out from the mass spectral data. An overall mass window is superimposed upon the mass spectral data. The overall mass window preferably comprises 21 nominal mass windows each preferably having a width of 1.0005 amu. Each nominal mass window preferably comprises 20 channels. An intensity distribution relating to all the first channels of the 21 nominal mass windows is determined. An intensity quantile is determined from the intensity distribution. The intensity quantile is taken to represent the background intensity in the first channel of the central nominal mass window. This process is repeated for the other channels so that the background intensity across the whole of the central nominal mass window is estimated and then subtracted from the raw mass spectral data comprising the central nominal mass window. The overall mass window is then preferably advanced approximately 1 amu and the process is repeated multiple times.
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Combined Search and Examination Report under Sections 17 and 18(3), dated Apr. 7, 2005.
Kast et al, Noise Filtering Techniques for Electrospray Quadrupole Time of Flight Mass Spectra, J. Am. Soc. Mass Spectrom. 2003, 14, 766-776.
Denny Richard
Richardson Keith
Skilling John
Berman Jack
Johnston Phillip A.
Micromass UK Limited
Rose Jamie H.
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