Mass spectral analysis of complex samples containing large...

Radiant energy – Ionic separation or analysis – Methods

Reexamination Certificate

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C250S281000, C250S288000, C702S002000, C702S022000, C702S030000

Reexamination Certificate

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07910877

ABSTRACT:
The present invention provides, inter alia, methods of analyzing mass spectral data based on charge states of analyte ions. In some embodiments, the methods can be used for differential profiling of samples, such as comparing a sample comprising a given compound and a sample comprising metabolites of the same compound. The methods can also be used to identify and isolate biomarkers. Systems for performing the methods, as well as computer-readable media for performing the methods, are also described.

REFERENCES:
patent: 7653496 (2010-01-01), Li
patent: 2003/0139885 (2003-07-01), Brock et al.
patent: 2007/0176088 (2007-08-01), Li
Ferrige, A.G. et al., Maximum Entropy Deconvolution in Electrospray Mass Spectrometry, Rapid Communications in Mass Spectrometry, 1991, pp. 374-379, vol. 5.
Mann, Matthias et al., Interpreting Mass Spectra of Multiply Charged Ions, Analytical Chemistry, Aug. 1, 1989, pp. 1702-1708, vol. 61, No. 15.

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