Mass determination for biopolymers

Details Mass determination for biopolymers Mass determination for biopolymers

2008-04-29

2008-04-29

Smith, Carolyn L. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C702S023000, C702S027000, C702S032000, C702S189000, C250S281000, C436S086000

Reexamination Certificate

active

10292374

ABSTRACT:
A method for determining the masses of ions of a sample that contains a known class of biopolymers and is measured with a mass spectrometer having a statistical or pseudo-statistical error distribution includes acquiring a mass spectrum of ions of biopolymers of the known class in the sample in which mass spectrum the mass values of ions of biopolymers from the known class are concentrated in known distributions around a set of most probable mass values. At least one measured mass value of the mass spectrum is replaced by that one of a set of most probable mass values that is nearest to the measured mass value, or by a weighted average of the measured mass value averaged with that one of the set of most probable mass values that is nearest to the measured mass value.

REFERENCES:
patent: 1 047 107 (2000-10-01), None
patent: 2 308 917 (1997-07-01), None
patent: WO 01/79523 (2001-10-01), None
Bruce et al. Obtainig More Accurate Fourier Transform Ion Cyclotron Resonance Mass Measurements Without Internal Standards Using Multiply Charged Ions. Journal of American Society for Mass Spectrometry. May 2000, vol. 11, pp. 416-421.
Mann, M., “Useful Tables of Possible and Probable Peptide Masses”, 43rdASMS Conference on Mass Spectrometry and Allied Topics, p. 639, 1995.

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