Mass defect labeling for the determination of oligomer...

Details Mass defect labeling for the determination of oligomer... Mass defect labeling for the determination of oligomer...

2008-01-08

2008-01-08

Gakh, Yelena G. (Department: 1743)

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

C436S015000

Reexamination Certificate

active

07316931

ABSTRACT:
Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.

REFERENCES:
patent: 4830010 (1989-05-01), Marshall
patent: 4842701 (1989-06-01), Smith et al.
patent: 4994165 (1991-02-01), Lee et al.
patent: 5100778 (1992-03-01), Rademacher et al.
patent: 5174962 (1992-12-01), Brennan
patent: 5306412 (1994-04-01), Whitehouse et al.
patent: 5386832 (1995-02-01), Wagner et al.
patent: 5470753 (1995-11-01), Sepetov et al.
patent: 5505832 (1996-04-01), Laukien et al.
patent: 5538897 (1996-07-01), Yates, III et al.
patent: 5667984 (1997-09-01), Parekh et al.
patent: 5691141 (1997-11-01), Koster
patent: 5700642 (1997-12-01), Monforte et al.
patent: 5827659 (1998-10-01), Patterson
patent: 5856082 (1999-01-01), Aebersold et al.
patent: 5872010 (1999-02-01), Karger et al.
patent: 5919709 (1999-07-01), Parmelee et al.
patent: 6004770 (1999-12-01), Nelson
patent: 6017693 (2000-01-01), Yates, III et al.
patent: 6027890 (2000-02-01), Ness et al.
patent: 6056926 (2000-05-01), Sugarman et al.
patent: 6090558 (2000-07-01), Butler et al.
patent: 6194144 (2001-02-01), Koster
patent: 6277644 (2001-08-01), Farnsworth et al.
patent: 6329146 (2001-12-01), Crooke et al.
patent: 6335525 (2002-01-01), Takada et al.
patent: 6359111 (2002-03-01), Meyer et al.
patent: 6379971 (2002-04-01), Schneider et al.
patent: 6391649 (2002-05-01), Chait et al.
patent: 2005/0147985 (2005-07-01), Pappin et al.
patent: 2004-52809 (2004-07-01), None
patent: 2004-203897 (2004-07-01), None
patent: 2004-519665 (2004-07-01), None
patent: 2004-520120 (2004-07-01), None
patent: 2004-520903 (2004-07-01), None
patent: 2004-521062 (2004-07-01), None
patent: 2004-521616 (2004-07-01), None
patent: 2004-522980 (2004-07-01), None
Intregrated Publishing. Nuclear Power Fundamentals. http://www.tpub.com/content/doe/h1019v1/css/h1019v1—45.htm.
Hughey et al. “Kendrick Mass Defect Spectrum: A Compact Visual Analysis for Ultrahigh-Resolution Broadband Mass Spectra”, Anal Chem., 2001, v. 73, pp. 4676-4681.
Graham D, et. al, “The Insulin-like Growth Factor (IGF) Blinding Site of Bovine Insulin-like Growth Factor Binding Protein-2 (bIGFBP-2) Probed by Iodination”, The Journal of Biological Chemistry, Nov. 29, 1996, vol. 271, No. 48, pp. 30529-30536.
Kristina A, et. al, “Sequencing of Sulfated Oligosaccharides from Mucins by Liquid Chromatography and Electrospray Ionization Tandem Mass Spactrometry”, Analytical Chemistry, Oct. 1, 2000, vol. 72, No. 19, pp. 4543-4549.
Scott A Gerber et al., “Absolute quantification of proteins and phosphoproteins from cell Iysates by tandem MS”, Proceedings of the National Academy of Sciences of the United States of America, Jun. 10, 2003, vol. No. 12, pp. 6940-6945.
Steven P. Gygi et al., “Quantitative analysis of complex protein mixtures using isotope-coded affinity tags”, Nature America Inc., Jul. 13, 1999, vol. 17, pp. 994-999.
Shao-En Ong et al., “Stable Isotope labeling by Amino Acids in Cell Culture, SILAC, as Simple and Accurate Approach to Expression Proteomics*”, Molecular & Cellular Proteomics Jan. 5, 2002, pp. 376-386.
Olga A. Mirgorodskaya et al., “Quantitation of peptides and proteins by matrix assisted laser desorption/ionization mass spectrometry using O-labeled internal standards”, Rapid Communications in Mass Spectrometry, 2000, pp. 1226-1232.
Fred E. Regnier et al., “Global internal standard technology for comparative proteomics”, Journal of Chromatography A, 2002, pp. 173-184.

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