Mass analysis using alternating fragmentation modes

Radiant energy – Ionic separation or analysis – Methods

Reexamination Certificate

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C250S283000, C435S024000

Reexamination Certificate

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07943900

ABSTRACT:
A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Transfer Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Transfer Dissociation fragmentation device.

REFERENCES:
patent: 6348688 (2002-02-01), Vestal
patent: 6906319 (2005-06-01), Hoyes
patent: 7196326 (2007-03-01), Franzen et al.
patent: 7534622 (2009-05-01), Hunt et al.

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