Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2006-05-30
2009-02-03
Berman, Jack I (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S281000, C250S286000, C250S288000, C422S068100, C422S070000, C702S023000, C702S027000
Reexamination Certificate
active
07485852
ABSTRACT:
The present invention achieves a mass analysis method that can identify protein or peptide with high speed and high sensitivity. A mass spectrum is obtained from a standard sample of healthy person, an ion is selected from the mass spectrum as a precursor ion, and a mass spectrum of the precursor ion is obtained [(a) to (d)]. A mass spectrum is obtained from a sample of interest to be measured of patient, an ion other than the precursor ion of the standard sample is selected from the mass spectrum as a precursor ion, and a mass spectrum of the precursor ion is obtained [(g) to (k)]. Identifications on peptide/protein specific to the standard sample and the sample to be measured, and common to both are conducted [(r) to (q)], and based on the results, comparative analysis on peptide/protein of the sample to be measured (t). Without regarding an ion derived from all components of the sample to be measured as precursor ion, MS/MS spectrum is obtained and identification on a plurality of components of the sample to be measured can be conducted for a short time and with high sensitivity.
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Kobayashi Kinya
Kurosawa Tomoyuki
Takeda Akihiro
Yamashita Hiromichi
Berman Jack I
Hitachi High-Technologies Corporation
Logie Michael J
McDermott Will & Emery LLP
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