Mass analysis apparatus and method for mass analysis

Radiant energy – Ionic separation or analysis – With sample supply means

Reexamination Certificate

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C250S281000

Reexamination Certificate

active

11328151

ABSTRACT:
A mass analysis apparatus comprising a first ion source which ionizes a sample and produces sample ions, a second ion source which produces reactant ions having a polarity opposite to the polarity of the sample ions, and a mass spectrometer, wherein said second ion source is provided between said first ion source and said mass spectrometer apart from the axis of a flow of the sample ions discharged from said first ion source and emits reactant ions to the flow of sample ions discharged from said first ion source.

REFERENCES:
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patent: WO 99/13492 (1999-03-01), None
**Stephenson, et al., “Ion/Ion Proton Transfer Reactions for Protein Mixture Analysis” Analytical Chemistry, vol. 68, No. 22, pp. 4026-4032, Nov. 15, 1996.
**Stephenson, et al., “Adaptation of the Paul Trap for Study of the Reaction of Multiply Charge Cations with Singly Charged Anions” International Journal of Mass Spectrometry and Ion Processes, vol. 162, pp. 89-106, (1997).
**Ebeling, et al., “Corona Discharge in Charge Reduction Electrospray Mass Spectrometry” Analytical Chemistry, vol. 72, No. 21, pp. 5158-5161, Nov. 1, 2000.
**Scalf, et al., “Controlling Charge States of Large Ions” Science, vol. 283, pp. 194-197, Jan. 8, 1999.

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