Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-09-01
1995-11-28
Draper, Garnette D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2431, 4353201, 4352523, 4352401, 530350, 530828, 930250, 930 10, 935 9, C12N 121, C12N 510, C12N 1515, C07K 1447
Patent
active
054709709
ABSTRACT:
An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and antibodies in diagnostic, screening, and therapeutic methods.
REFERENCES:
patent: 4888278 (1989-12-01), Singer et al.
Z. Zou et al. Science 263:526 Jan. 28, 1994.
A. C. Webb et al. J. Exp Med 166:77-94 1987.
Band and Sager, Distinctive Traits of Normal and Tumor-derived Human Mammary Epithelial Cells Expressed in a Medium that Supports Long-term . . . Growth of Both Cell Types, Proc. Natl. Acad. Sci. USA 86:1249-1253, 1989.
Band et al., Tumor Progression in Four Mammary Epithelial Cell Lines Derived from the Same Patient, Cancer Research, 50:7351-7357, 1990.
Band et al., A Newly Extablished Metastatic Breast Tumor Cell Line with Integrated Amplified Copies of ERBB2 and Double Minute Chromosomes, Genes, Chromosomes & Cancer 1:48-58, 1989.
Baumann et al., Crystal Structure of Cleaved Human .alpha..sub.1 -Antichymotrypsin at 2-7 .ANG.Resolution and its Comparison with Other Serpins, J. Mol. Biol. 218:595-606, 1991.
Baylin et al., Hypermethylation of the 5' Region of the Calcitonin Gene is a Property of Human Lymphoid and Acute Myloid Malignancies, Blood 70:412-417, 1987.
Calabretta et al., Molecular Cloning of the cDNA for a Growth Factor-inducible Gene with Strong Homology to S-100, a Calcium-binding Protein, J. Biol. Chem. 261:12628-12632, 1986.
Carr et al., The Tumorigenicity of 5-azacytidine in the Male Fischer Rat, Carcinogenesis 5:1583-1590, 1984.
Cattaneo et al., Altered Ratios of Measles Virus Transcripts in Diseased Human Brains, Virology 160:523-526, 1987.
Cowan et al., Similar Biochemical Changes Associated with Multidrug Resistance in Human Breast Cancer Cells and Carcingen-induced Resistance to Xenobiotics in Rats, Proc. Natl. Acad. Sci. USA 83:9328-9322, 1986.
El-Deiry et al., High Expression of the DNA Methyltransferase Gene Characterizes Human Neoplastic Cells and Progession Stages of Colon Cancer, Proc. Natal. Acad. Sci. USA 88:3470-3474, 1991.
Friedmann, Gene Therapy, Therapy for Genetic Disease, pp. 107-121.
Gibbs et al., Characterization of the Human spr2 Promoter: Induction after UV Irradiation or TPA Treatment and Regulation During Differentiation of . . . Primary Keratinocytes, Nucleic Acids Res. 18:4401-4407, 1990.
Harrison et al., Azacytidine-Induced Tumorigenesis of CHEF/18 Cells: Correlated DNA Methylation and Chromosome Changes, Proc. Natl. Acad. Sci. USA 80:6606-6610, 1983.
Hendrix et al., A Simple Quantitative Assay for Studying the Invasive Potential of High and Low Human Metastatic Varients, Cancer Letters 38:137-147, 1987.
Huber et al., Implication of the Three-Dimensional Structure of .alpha..sub.1 -Antitrypsin for Structure and Function of Serpins, Biochemistry 28:8951-8966, 1989.
Jones and Buckley, The Role of DNA Methylation in Cancer, Advances in Cancer Research 54:1-23, 1990.
Kligman and Hilt, The S100 Protein Family, Trends in Biochemical Sciences 13:437-443, 1988.
Lee et al., Down-regulation of a Member of the S100 Gene Family in Mammary Carcinoma Cells and Reexpression by Azadeoxycytidine Treatment, Proc. Natl. Acad. Sci. USA 89:2504-2508, 1992.
Lee et al., Positive Selection of Candidate Tumor-Suppressor Genes by Subtractive Hybridization, Proc. Natl. Acad. Sci. USA 88:2825-2829, 1991.
Lee et al., Isolation and Characterization of Eight Tumor Necrosis Factor-Induced Gene Sequences from Human Fibroblasts, Molecular and Cellular Biology 10:1982-1988, 1990.
Lersch and Fuchs, Sequence and Expression of a Type II Keratin, K5, in Human Epidermal Cells, Molecular and Cellular Biology 8:486-493, 1988.
Liotta and Stetler-Stevenson, Tumor Invasion and Metastasis: An Imbalance of Positive and Negative Regulation, Cancer Reserach(Suppl.) 51:5054s-5059s, 1991.
Lobermann et al., Human .alpha..sub.1 -Proteinase Inhibitor, J. Mol. Biol. 177:531-556, 1984.
Moscow et al., Expression of Anionic Glutathione-S-transferase and P-Glycoprotein Genes in Human Tissues and Tumors, Cancer Research 49:1422-1428, 1989.
Mottonen et al., Structural Basis of Latency in Plasminogen Activator Inhibitor-1, Nature 355:270-273, 1992.
Price et al., Tumorigenicity and Metastasis of Human Breast Carcinoma Cell Lines in Nude Mice, Cancer Research 50:717-721, 1990.
Remond-O'Donnell et al., Sequence and Molecular Characterization of Human Monocyte/Neutrophil Elastase Inhibitor, Proc. Natl. Acad. Sci. USA 89:5635-5639, 1992.
Sager et al., Identification by Differential Display of Alpha 6 Integrin as a Candidate Tumor Suppressor Gene, FASEB J. 7:964-970, 1993.
Sager, Tumor Suppressor Genes: The Puzzle and the Promise, Science 246:1406-1412, 1989.
Saheki et al., Primary Structure of the Human Elafin Precursor Preproelafin Deduced from the Nucleotide Sequence . . . Repetitive Sequences in the Prosegment, Biochem. & Biophys. Research Comm. 185:240-245, 1992.
Stein et al., Crystal Structure of Ovalbumin as a Model for the Reactive Centre of Serpins, Nature 347:99-102, 1990.
Testa and Quigley, The Role of Urokinase-type Plasminogen Activator in Agressive Tumor Cell Behavior, Cancer and Metastasis Reviews 9:353-367, 1990.
Tomasetto et al., Specificity of Gap Junction Communication Among Human Mammary Cells and Connexin Transfectants in Culture, J. Cell Biol. 122:157-167, 1993.
Trask et al., Keratins as Markers that Distinguish Normal and Tumor-derived Mammary Epithelial Cells, Proc. Natl. Acad. Sci. USA 87:2319-2323, 1990.
Travis et al., Serpins: Structure and Mechanism of Action, Biological Chemistry Hoppe-Seyler 371(Suppl.): 3-11, 1990.
Tsunemi et al., Synthesis and Structure-Activity Relationships of Elafin, an Elastase-Specific Inhibitor, Biochemical and Biophysical Research Communications 185:967-973, 1992.
Wiedow et al., Elafin: An Elastase-specific Inhibitor of Human Skin, J. Biol. Chem. 265:14791-14795, 1990.
Wright et al., Crystal Structure of Plakalbumin, a Proteolytically Nicked Form of Ovalbumin, J. Mol. Biol. 213:513-528, 1990.
Yaswen et al., Down-regulation of a Calmodulin-related Gene During Transformation of Human Mammary Epithelial Cells, Proc. Natl. Acad. Sci. USA 87:7360-7364, 1990 numerous passages eligble.
Zhang and Nicholson, Sequence and Tissue Distribution of a Second Protein of Hepatic Gap Junctions, Cx26, As Deduced from its cDNA, J. Cell Biol. 109:3391-3401, 1989.
Anisowicz Anthony
Sager Ruth
Zou Zhiqiang
Dana-Farber Cancer Institute Inc.
Draper Garnette D.
Spector Lorraine M.
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