Marker molecules associated with lung tumors

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S254110, C435S320100, C435S325000, C530S350000

Reexamination Certificate

active

07355025

ABSTRACT:
The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts of the gene disclosed herein, that are associated with tumors of the respiratory tract. Furthermore the present invention provides a method for early diagnosis, prognosis and monitoring of the disease course and for therapy and vaccination of cell proliferative disorders such as e.g. lung tumors.

REFERENCES:
patent: 4281061 (1981-07-01), Zuk et al.
patent: 6033847 (2000-03-01), Sherr et al.
patent: 6316208 (2001-11-01), Roberts et al.
patent: 6436703 (2002-08-01), Tang et al.
patent: 2002/0061567 (2002-05-01), Tang et al.
patent: 2002/0146757 (2002-10-01), Tang et al.
patent: 2003/0049617 (2003-03-01), Chen et al.
patent: 2003/0087370 (2003-05-01), Tang et al.
patent: 2003/0092112 (2003-05-01), Tang et al.
patent: 2003/0096279 (2003-05-01), Tang et al.
patent: 2003/0157482 (2003-08-01), Keesee et al.
patent: 2003/0180722 (2003-09-01), Godbole et al.
patent: WO 01/61055 (2001-08-01), None
patent: WO 01/75067 (2001-10-01), None
Srebrow et al (J. Cell Sci., 119:2635-2641, 2006).
Kirschbaum-Slager et al (Gen. Mol. Res., 3(4):512-520, 2004).
Kalnina et al (Gen. Chrom. Can., 42:342-357, 2005).
Harrington et al (Nat. Biotech., 19:440-445, 2001).
Harrington et al, GenBankTM Accession No. BG181290, pp. 1-2, 2001.
NCI-CGAP, GenBankTM Accession No. AW189129, pp. 1-2, 1999.
Verma et al. (Nature 1997, 389: 239-242).
Amalfitano et al. (Current Gene Therapy 2002, 2: 111-133).
Patterson, Department of Health and Human Services memorandum, Jan. 2003, pp. 1-3.
Pandha et al. (Current Opinion in Investigational Drugs 2000; 1 (1): 122-134).
Ferrari et al. (Clin. Exp. Immunol. 2003; 132: 1-8).
Arakawa, et al., “Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library . . . ”, EMBL Online, Oct. 21, 2001, accession No. BB653919, XP002219900, abstract.
NCI-MGC: “602891694F1 NCI—CGAP—Lu29 Mus musculus cDNA clone IMAGE:50367110 5′, mRNA sequence”, EMBL Online, Jun. 28, 2001, accession No. Bi107698, XP002219901, abstract.
Tracey A: “Human DNA sequence from clone RP11-425D10 on chromosome 6”, EMBL Online, Mar. 1, 2001, accession No. AL359711, XP002219902, abstract.
Drmanac et al., “DNA encoding novel human diagnostic protein #5135”, EMBL Online, Feb. 13, 2002, accession No. AAS69331, XP002219903, abstract.
He, et al., “Expression, Deletion And Mutation of p16 Gene in Human Gastric Cancer”World J. of Gastroenterology 7(4): 515-521 (2001).
Myung, et al., “Loss Of p16 And p27 Is Associated With Progression Of Human Gastric Cancer”Cancer Letters 153:129-136 (2000).
Nakao et al., “Induction of p16 During Immortalization HPV 16 and 18 and Not During Malignant Transformation”British J of Cancer 75(10):1410-1416, 1997.
O'Nions, et al., “p73 Is Over-Expressed In Vulval Cancer Principally As The Δ2 Isoform”British J. Cancer 85(10):1551-1556 (Nov. 2001).
Sano et al., “Expression Status of p16 Protein Is Associated With Human Papillomavirus Oncogenic Potential In Cervical and Genital lesions”American J. Pathology 153(6):1741, 1998.
Sano, et al., “Overexpression Of P16 And P14ARF Is Associated With Human Papillomavirus Infection In Cervical Squamous Cell Carcinoma And Dysplasia”Pathology.Int. 52:375-383 (May 2002).
Sherr, “The Ink4a/Arf Network In Tumor Suppression”Nature Reviews Mol. Cell Bio 2:731-737, (2001).
Takeuchi, et al., “Altered p16/MTSi/CDKN2 and Cycling D1/PRAD-1 Gene Expression Is Associated With The Prognosis of Squamous Cell Carcinoma of the Esophagus”Clinical Cancer Research 3:2229-2236, (1997).
Tsujie, et al., “Expression of Tumor Suppressor Gene p16INK4 Products in Primary Gastric Cancer”Oncology 58:126-136 (2000).
NCI-CGAP: 7q79d11.x1 NCI—CGAP—LU24Homo sapienscDNA clone IMAGE: 3704516 3′, mRNA sequence, XP002261497, abstract, Apr. 2, 2001.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Marker molecules associated with lung tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Marker molecules associated with lung tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Marker molecules associated with lung tumors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2776038

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.