Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1996-01-25
1998-06-02
Davenport, Avis M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530327, 530328, 530329, A61K 3800, C07K 500, C07K 700
Patent
active
057601887
ABSTRACT:
The present invention relates to compound having the formula: ##STR1## or a pharmaceutically acceptable acid salt thereof, wherein R is a polypeptide moiety comprises an amino acid sequence:
REFERENCES:
Faure et al., Binding and Internalization of Neurotensin in Hybrid Cells Derived from Septal Cholinergic Neurons, Chemical Abstracts, vol. 118, No. 13., 1993, Abst No: 117032h.
Carraway, R. & Leeman, S.E., The J. of Biol. Chem., 1973, 248:6854-6861.
Tanaka, Masu, and Nakanishi, Neuron, 1990, 4:947-854.
Hazum E., Chang K-J, & Cuatrecas P., Proc. of Natl. Acad. Sciences USA, 1979, 77:3038-3041.
Taylor D.L. & Wang Yu-Li, Nature, 1980, 284:405-410.
Schaffner et al., The J. of Neuroscience, 1987, 7:3088-3104.
Sadoul J.L. et al., Biochem. and Biophys. Res. Comm., 1984, 120(1):206-213.
Hammond et al., Science, Dec. 1986, 234:1237-1240.
Beaudet Alain
Faure Marie-Pierre
Gaudreau Pierrette
Davenport Avis M.
Martin R&F Inc.
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