Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-08-31
1998-04-07
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 74, 435 911, 435 912, 435810, 435975, 435183, 5303871, 5303881, 53038826, 53038885, 536 231, 536 235, 536 2431, 536 2433, 536 253, 935 76, 935 77, 935 78, C12Q 168, G01N 33573, C07H 2104, C12N 1500
Patent
active
057363250
ABSTRACT:
The present invention relates to methods for diagnosis of susceptibility to alcoholism or the pathological effects of alcoholism based on detection of a genetic marker in an individual. The present invention is directed generally to methods and associated compositions and kits for detecting the presence of arylsulfatase A (ASA) pseudodeficiency (PD) mutations in humans. Detection of these mutations has been surprisingly found to be a strong indicator for susceptibility to alcoholism and/or susceptibility to alcohol's pathological effects, as well as an important marker in evaluating the likelihood of metachromatic leukodystrophy (MLD).
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Manowitz Paul
Park David
Poretz Ronald D.
Ricketts Michael
Algene LLC
Sisson Bradley L.
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