Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1990-01-22
1991-02-26
Kepplinger, Esther L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530413, 530828, C07K 1514, C12P 2106
Patent
active
049962981
ABSTRACT:
A new marker for colorectal carcinoma has been discovered which is a goycoprotein having a molecular weight of approximately 160,000 daltons. Assay methods which can identify this marker are useful in detecting, diagnosing, and monitoring colorectal carcinoma, and in particular, carcinoma of the undifferentiated variety which heretofor were not readily detectible. For example, an assay which utilizes an antibody reacting to this glycoprotein marker is useful in a screening method for the detection and monitoring of colorectal carcinoma cells. Such an antibody can be included as part of a kit for screening a patient for colorectal carcinoma.
REFERENCES:
patent: 4363799 (1982-12-01), Kung et al.
Ho et al., Cancer Research, vol. 42, Jan. 1, 1987, pp. 241-250.
Blaszczyk et al., Cancer Research, vol. 44, Jan., 1984, pp. 245-253.
Kobari et al., Biological Abstracts, vol. 82(2), 1986, Abstract No. 15152.
DeLellis et al. (1987), Seminars in Oncology 14: 173-192.
Niles et al. (1987), Cancer Investigation 5: 545-552.
Schoentag et al. (1987), Cancer Research 47: 1695-1700.
Vecchi et al. (1987), Proc. Natl. Acad. Sci. U.S.A. 84: 3425-3429.
Abe, et al. (1986), Cancer Research 46: 2639-2644.
Bleday et al. (1986), Cancer, 57: 433-440.
Itzkowitz et al. (1986), Cancer Research 46: 2627-2632.
Rogers et al. (1986), Cancer Immunol. Immunother. 23: 107-112.
Sakamoto et al. (1986) Cancer Research 46: 1553-1561.
Yuan et al. (1985), Cancer Research 45: 4499-4511.
Nadakavukaren et al. (1984), Differentiation 27: 209-220.
Fredman et al. (1983) The Journal of Biological Chemistry 258: 11206-11210.
Wagener et al. (1983), The Journal of Immunology 130: 2308-2315.
Herlyn et al. (1982), Proc. Natl. Acad. Sci. U.S.A. 79: 4761-4765.
Kurzinger et al. (1982), The Journal of Biological Chemistry 257: 12412-12418.
Goslin et al. (1981), The American Journal of Medicine 71: 246-253.
Hsu et al. (1981), The Journal of Histochemistry and Cytochemistry 29: 1349-1353.
Kupchik et al., (1981), Cancer Research 41: 3306-3310.
Morrison (1980), Methods in Enzymology 70: 214-220.
Herlyn et al. (1979) Eur. J. Immunol. 9: 657-659.
Springer et al. (1979) Journal of Surgical Oncology 11: 95-106.
Ey et al. (1978) Biochemistry 15: 429-436.
Springer et al. (1977), Clinical Immunology and Immunopathology 7: 426-441.
Search Report (Paper Chase) Relating Generally to the Field of Tumor-Specific Antigens.
Salem et al. (1987) Surgical Forum (Oct.), pp. 408-410.
Salem et al. (1987) Proceedings of AACR vol. 28-Immunology, Abstract No. 1571.
Salem Ronald R.
Steele Glenn
Thomas Peter
Hoffer Florina B.
Kepplinger Esther L.
New England Deaconess Hospital Corporation
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