Marker for antidepressant therapy and methods related thereto

Details Marker for antidepressant therapy and methods related thereto Marker for antidepressant therapy and methods related thereto

2005-04-05

2005-04-05

Gitomer, Ralph (Department: 1651)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S029000

Reexamination Certificate

active

06875566

ABSTRACT:
The present invention relates generally to methods for determining the effectiveness of ongoing antidepressant therapy via analysis of the association of Gsαwith components of the plasma membrane or cytoskeleton of cells from peripheral tissues of the depressed individual as well as to methods involved in screening for effective antidepressant agents via their ability to cause a difference in the association of Gsαwith components of the plasma membrane or cytoskeleton of cells.

REFERENCES:
patent: 6034071 (2000-03-01), Iyengar
patent: 6071722 (2000-06-01), Elshourbagy et al.
patent: 6107076 (2000-08-01), Tang et al.
patent: 6448377 (2002-09-01), Kobilka et al.
patent: 20020061599 (2002-05-01), Elling et al.
patent: WO 9720211 (1997-06-01), None
Toki, S. Treatment of C6 Glioma Cells . . . J of Neurochem 73(3)1114-1120, Aug. 20, 1999.*
Chen J. Chronic Antidepressant Treatment Facilitates G Protein Activation of Adenylyl Cyclase Without Altering G Protein Content. J of Pharmacology and Experimental Therapeutics. 1995, 275(1)509-517.*
Chen J. Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Increases Functional Coupling Between a G Protein and Adenylyl Cyclase. J of Neurochemistry 64(2)724-732, 1995.*
Young L. Lack of Effect of Antidepressants on Mononuclear Leukocyte G Protein Levels or Function in Depressed Outpatients. J of Affective Disorders 39(3)201-206, 1996.*
Rasenick M. G Protein Mediated Signal Transduction as a Target of Antidepressant and Antibipolar Drug Action: Evidence from Model Systems. J Clinical Psychiatry vol. 57, Suppl 13, pp. 49-55, 1996.*
Kamada H. Alterations of Tubulin Funcdtion Caused by Chronic Antidepressant Treatment in Rat Brain. Cellular and Molecular Neurobiology 19(1)109-117, 1999.*
Avissar et al., “Interaction of Antibipolar and Antidepressant Treatments with Receptor-Coupled G Proteins,” Pharmacopsychiat., 25:44-50 (1992).
Carlson, et al., “Fractionation of the Beta Subunit Common to Guanine Nucleotide-Binding Regulatory Proteins with the Cytoskeleton,”Mol. Pharmacol.,30:463-468 (1986).
Chen, et al., “Chronic Antidepressant Treatment Facilitates G Protein Activation of Adenylyl Cyclase without Altering G Protein Content,”J. Pharm. Exp. Ther.,275:509-517 (1995).
Chen, et al., “Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Increases Functional Coupling Between a G Protein (GS) and Adenylyl Cyclase,”J. Neurochem.,64:724-732 (1995).
Cowburn, et al., “Adenylyl Cyclase Activity and G-protein Subunit Levels in Postmortem Frontal Cortex of Suicide Victims,”Brain Res.,633:297-304 (1994).
De Montis, et al., “Selective Adenylate Cyclase Increase in the Limbic Area of Long-term Imipramine-treated Rats,”Eur. J. Pharmacol.,180:169-174 (1990).
Donati, et al., “Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Results in a Redistribution of Gsα,”Molecular Pharmacology,59:1426-1432 (2001).
Duman, et al., “A Molecular and Cellular Theory of Depression,”Arch. Gen. Psychiatry,54:597-606 (1997).
Emamghoreishi, et al., “Lack of Effect of Chronic Antidepressant Treatment of Gs and Gi Alpha-subunit Protein and mRNA Levels in the Rat Cerebral Cortex,”Neuropsychopharmacology,15:281-287 (1996).
Jenkinson, et al., “Two Affinities for a Single Antagonist at the Neuronal NK1 Tachykinin Receptor: Evidence from Quantitation of Receptor Endocytosis,”Br. J. Pharmacol.,126:131-136 (1999).
Kuo, et al., “Force of Single Kinesin Molecules Measured with Optical Tweezers,”Science,260:232-234 (1993).
Lee, et al., “Expression of G-protein Alpha Subunits ofEscherichia coli,” Methods Enzymol.,237:146-164 (1994).
Li, et al., “Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin,”J. Biol. Chem.,270:15693-15701 (1995).
Menkes, et al., “Guanosine Triphosphate Activation of Brain Adenylate Cyclase: Enhancement by Long-Term Antidepressant Treatment,”Science,219:65-67 (1983).
Neubig, R. R., “Membrane Organization in G-protein Mechanisms,”J. FASEB,8:939-946 (1994).
Okamoto, et al., “Caveolins, a Family of Scaffolding Proteins for Organizing ‘Preassembled Signaling Complexes’ at the Plasma Membrane,”J. Biol. Chem.,273:5419-5422 (1998).
Ozawa, et al., “Chronic Electroconvulsive Treatment Augments Coupling of the GTP-Binding Protein Gs to the Catalytic Moiety of Adenylyl Cyclase in a Manner Similar to That Seen with Chronic Antidepressant Drugs,”J. Neurochem.,56:330-338 (1991).
Ozawa, et al., “Coupling of the Stimulatory GTP-Binding Protein GSto Rat Synaptic Membrane Adenylate Cyclase is Enhanced Subsequent to Chronic Antidepressant Treatment,”Mol. Pharm.,36:803-808 (1989).
Perez, et al., “cAMP Binding Proteins in the Rat Cerebral Cortex After Administration of Selective 5-HT and NE Reuptake Blockers with Antidepressant Activity,”Neuropsychopharmacology,4:57-64 (1991).
Perez, et al., “cAMP Dependent Phosphorylation of Soluble and Crude Microtubule Fractions of Rat Cerebral Cortex After Prolonged Desmethylimipramine Treatment,”Eur. J. Pharmacol.,172:305-316 (1989).
Popova, et al., “Muscarinic Receptor Activation Promotes the Membrane Association of Tubulin for the Regulation of Gq-Mediated Phospholipase Cβ1Signaling,”J. of Neuroscience,20:2774-2782 (2000).
Popova, et al., “Tubulin, Gq, and Phosphatidylinositol 4,5-Bisphosphate Interact to Regulate Phospholipase Cβ1Signaling,”J. Biol. Chem.,272:6760-6765 (1997).
Rasenick, et al., “G Protein-Mediated Signal Transduction as a Target of Antidepressant and Antibipolar Drug Action: Evidence from Model Systems,”J. Clin. Psychiatry,57:49-55 (1996).
Rasenick, et al., “Guanine Nucleotide Activation of Adenylate Cyclase in Saponin Permeabilized Glioma Cells,”FEBS Letters,207:296-301 (1986).
Rasenick, et al., “Guanosine-5′-O-thiodiphosphate Functions as a Partial Agonist for the Receptor-independent Stimulation of Neural Adenylate Cyclase,”Brain Res.,488:105-113 (1989).
Rasenick, et al., “Specific Associations between Tubulin and G Proteins: Participation of Cytoskeletal Elements in Cellular Signal Transduction,”Adv. Second Messenger Phophoprotein Res.,24:381-386 (1990).
Rasenick, et al., “The Regulatory Subunit for Adenylate Cyclase Interacts with Cytoskeletal Components,”Nature,294:560-562 (1981).
Regula, et al., “Membrane Tubulin,”Ann. N.Y. Acad. Sci.,466:832-842 (1986).
Roychowdhury, et al., “G Protein α Subunits Activate Tubulin GTPase and Modulate Microtubule Polymerization Dynamics,”J. Biol. Chem.,274:13485-13490 (1999).
Roychowdhury, et al., “G Protein Binding and G Protein Activation by Nucleotide Transfer Involve Distinct Domains on Tubulin: Regulation of Signal Transduction by Cytoskeletal Elements,”Biochem.,32:4955-4961 (1993).
Roychowdhury, et al., “Tubulin-G Protein Association Stabilizes GTP Binding and Activates the GTPase: Cytoskeletal Participation in Neuronal Signal Transduction,”Biochem.,33:9800-9805 (1994).
Senda et al., “Alterations in the Detergent Extraction of G Protein from the Plasma Membrane From Postmortem Human Brains of Patients with Depression,” Society for Neuroscience Abstracts, 26(1-2) : Abstract (2000); 30thAnnual Meeting of the Society of Neuroscience, New Orleans, LA, USA, Nov. 4-9, 2000.
Southwell, et al., “Movement of Villi Induces Endocytosis of NK1 Receptors in Myenteric Neurons From Guinea-pig Ileum,”Cell Tissue Res.,292:37-45 (1998).
Sulser, F., “Antidepressant Treatments and Regulation of Norepinephrine-receptor-coupled Adenylate Cyclase Systems in Brain,”Adv. Biochem. Psychopharmol.,39:249-261 (1984).
Takahashi, et al., “Chronic Antidepressant Administration Increases the Expression of cAMP-Specific Phosphodiester

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