Marker at the estrogen receptor gene for determination of osteop

Details Marker at the estrogen receptor gene for determination of osteop Marker at the estrogen receptor gene for determination of osteop

1997-07-14

1998-11-10

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 243, 536 2431, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104

Patent

active

058342001

ABSTRACT:
The present invention relates to a method of determining predisposition to low or high bone mineral density and to development of osteoporosis of a patient, which comprises determining estrogen receptor polymorphism in linkage disequilibrium in a biological sample of said patient, wherein heterozygosity is associated with high bone density and homozygosity is associated with low bone density.

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Fleet et al. The Bsml Vitamin D Receptor Restriction Fragment Length Polymorphism (BB) Predicts Low Bone Density in Premenopausal Black and White Women. Journal of Bone and Mineral Research 10(6):985-990, 1995.
Yaich et al. Analysis of the Pvull Restriction Fragment-Length Polymorphism and Exon Structure of the Estrogen Gene in Breast Cancer and Peripheral Blood. Cancer Research 52:77-83, 1992.
Riggs et al. Involutional Osteoporosis. The New England Journal of Medicine 314(6):1676-1684, 1986.
Kobayashi et al. Association of Bone Mineral Density with Polymorphism of the Estrogen Receptor Gene. Journal of Bone and Mineral Research 11(3):306-311, 1996.

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