Marker and immunological reagent for dialysis-related amyloidosi

Details Marker and immunological reagent for dialysis-related amyloidosi Marker and immunological reagent for dialysis-related amyloidosi

1997-10-24

2000-03-07

Chin, Christopher L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 435 793, 435 14, 435343, 436518, 436 67, 436811, 5303896, 5303887, G01N 3353, G01N 3372, C07K 1618

Patent

active

060338628

ABSTRACT:
There are provided: an immunological reagent for diagnosis of or the evaluation of the effect of a medicine for dialysis-related amyloidosis, which includes an antibody which reacts specifically with a carboxymethylated .alpha.-amino acid, a carboxymethylated protein, or a carboxymethylated peptide; or, an immunological reagent for diagnosis of or the evaluation of the effect of a medicine for diabetes mellitus and diabetes mellitus complications, which includes an antibody which reacts specifically with an N.sup..alpha. -carboxymethylated .alpha.-amino acid, an N.sup..alpha. -carboxymethylated protein, or an N.sup..alpha. -carboxymethylated peptide. Methods using the immunological reagents are provided: for determination of carboxymethylated hemoglobin as a marker for dialysis-related amyloidosis; or, for determination of N.sup..alpha. -carboxymethylated hemoglobin as a marker for diabetes mellitus or diabetes mellitus complications.

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