Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-06-30
2008-11-25
Davis, Zinna N (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S422000, C424S001890, C546S278700, C548S404000
Reexamination Certificate
active
07456202
ABSTRACT:
Fluorine-18-labelled maleimide compounds of general formula (I):in which:m represents an integer from 0 to 10;n represents an integer from 1 to 10;Y represents a group selected from optionally substituted monocyclic or bicyclic heterocyclic groups;X represents a radical of formula:in-line-formulae description="In-line Formulae" end="lead"?(U)a—((CR1R2)b—(V)c)d—((CR3R4)e—(W)f)g—in-line-formulae description="In-line Formulae" end="tail"? in which:a, b, c, d, e, f and g represent each independently an integer from 0 to 10;U, V and W represent each independently —NR1—, —O—, —S—, ethynyl, —CR1═CR2—, —(C═O)—, —(C═S)—, —C(═NR1)—, —C(═O)O—, —(C═S)S—, —C(═NR1)NR2—, —CR1R2—, —CR1OR2— or —CR1NR2R3—.Process for preparing these compounds; their use for labelling macromolecules, and complexes of these compounds with a macromolecule.Detection and analysis kit, or diagnosis kit, comprising the said complexes.Use of the complexes in a medical imaging process such as positron emission tomography (PET).
REFERENCES:
patent: 4735792 (1988-04-01), Srivastava
patent: 5242680 (1993-09-01), Chorev
patent: 99 11590 (1999-03-01), None
Wilbur D S: “Rediohalogenation of Protein: An Overview of Radionuclides, Labeling Methods, and Reagents for Conjugate Labeling” Bioconjugate Chemistry, American Chemical Society, vol. 3, No. 6, pp. 433-470, Nov. 1, 1992. XP000328382.
C-Y Shiue: “Synthesis of 18F-labelled N-(p- ′18F!fluorophenyl)maleimide and its derivatives for labelling monoclonal antibody with 18F” Journal of Labelled Compounds and Radiopharmaceuticals, vol. 26, pp. 287-289, 1989. XP002091356.
Commissariat a l''Energie Atomique
Davis Zinna N
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
LandOfFree
Marked maleimide compounds, method for preparing same and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Marked maleimide compounds, method for preparing same and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Marked maleimide compounds, method for preparing same and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4048985