Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2007-05-04
2010-11-02
Mosher, Mary E (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S229100, C435S069100, C435S235100
Reexamination Certificate
active
07824690
ABSTRACT:
An effective vaccine for Marek's disease may be prepared using a viral agent which is a Marek's disease virus unable to express a functional meq protein. This viral agent is effective to elicit an immune response in a chicken to very virulent strains of Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.
REFERENCES:
Rispens et al. Avian Diseases. 1972; 16: 108-125.
Lee et al. Journal of Veterinary Medical Science. 2000; 62 (3): 287-292.
Chang et al. Journal of Veterinary Medical Science. 2002; 64 (12): 1091-1095.
Witter. Poultry Science. 1998; 77 (8): 1197-203.
Morgan, Robin W., et al, “Marek's Disease Virus gC and meq Mutants with Dramatic Reductions in Tumour Incidences and Horizontal Transmission”, Avian Pathology, vol. 27, Supplement 1, Apr. 1998, Proceedings of an International Symposium held to honour Dr. L.N. Payne.
Morgan , Robin, et al., “Clues to MDV Oncogenicity: MEQ Mutants and Molecular Differences Among MDV Serotype1 Isolates”, 2nd International Workshop on Molecular Pathogenesis of MDV, Aug. 8-11, 1998.
Lupiani Blanca M.
Reddy Sanjay M.
Deck Randall E.
Fado John D.
Hill Myron G
Mosher Mary E
Shaw Lesley
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