Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Reexamination Certificate
2007-05-08
2007-05-08
Campell, Bruce R. (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
C435S320100, C435S236000, C424S229100
Reexamination Certificate
active
10430773
ABSTRACT:
An effective vaccine for Marek's disease may be prepared using a viral agent which is a Marek's disease virus unable to express a functional meq protein. This viral agent is effective to elicit an immune response in a chicken to very virulent strains of Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.
REFERENCES:
Rispens et al. Avian Diseases. 1972; 16: 108-125.
Lee et al. Journal of Veterinary Medical Science. 2000; 62 (3): 287-292.
Chang et al. Journal of Veterinary Medical Science. 2002; 64 (12): 1091-1095.
Witter. Poultry Science. 1998; 77 (8): 1197-203.
Jones, Dan et al., “Marek disease virus encodes a basic-leucine zipper gene resembling thefos/junencogenes that is highly expressed in lympthoblastoid tumors”,Proc. Natl. Acad Sci. USA, vol. 89, pp. 4042-4046, May 1992.
Ferrin, Lance J. et al., “Selective Cleavage of Human DNA: RecA-Assisted Restriction Endonuclease (RARE) Cleavage”, Science, vol. 254, pp. 1494-1497.
Reddy, Sanjay et al., “Rescue of Pathogenic Marek's Disease virus with overlapping cosmid DNAs:Use of a pp38 mutant to validate the technology for the study of gene function”, PNAs Online, Published online before print May 7, 2002, Proc. Natl. Aacad. Sci. USA, vol. 99, Issue 10, 7054-7059, May 14, 2002, retrieved online [http://www.pnas.org/cgi/content/abstract/99/10/7054?maxtoshow=&HITS=10&hits=10&RES . . . 4/4/03], 10 pgs.
Lupiani Blanca M.
Reddy Sanjay M.
Campell Bruce R.
Deck Randall E.
Fado John
Hill Myron G.
Shaw Lesley
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