Marek's disease virus nucleotide sequence and methods of use

Chemistry: molecular biology and microbiology – Vector – per se

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4241991, 4242021, 4242291, 424816, 536 231, 536 2372, 930224, C12N 1586, C12N 1538, A61K 39255, A61K 39295

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active

056935307

ABSTRACT:
A novel nucleotide sequence in the genome of Marek's disease virus (MDV) containing an open reading frame, whose expression is associated with lytic infection and tumor cell development in MDV-infected cells, is described. Also described is the use of this novel sequence for molecular diagnostics of serotype 1 MDV; and to generate a recombinant MDV by inserting one or more endogenous or exogenous genes, operably linked to a control element for expression, into a region of the MDV genome comprising the novel nucleotide sequence, wherein the insertion interrupts expression of the open reading frame.

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Jones et al., "Marek Disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors", Proc. Nat. Acad. Sci., 89:4042-4046, May 1992.
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Sakaguchi et al., "Marek's Disease Virus protein kinase gene identified within the short unique region of the viral genome is not essential for viral replication in cell culture and vaccine-induced immunity in chickens", Virol. 195: 140-148, 1993.
Yanagida et al., "Recombinant fowlpox viruses expressing the glysoprotein B homolog and the pp.38 gene of Marek's Disease virus", J. Virol. 66(3): 1402-1408, Mar. 1992.
Pratt et al., "Characterization of Reticuloendotheliosis Virus-Transformed Avian T-Lymphoblastoid Cell Lines Infected with Marek's Disease Virus", Journal of Virology, vol. 66, No. 12, 1992, pp. 7239-7244.
Ohashi et al., "cDNA Clones Derived From The Marek's Disease Tumor Cell Line MDCC-CU41" in Proceedings XIX World's Poultry Congress, 1992, pp. 54-57.

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