Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-06-07
1997-12-02
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Vector, per se
4241991, 4242021, 4242291, 424816, 536 231, 536 2372, 930224, C12N 1586, C12N 1538, A61K 39255, A61K 39295
Patent
active
056935307
ABSTRACT:
A novel nucleotide sequence in the genome of Marek's disease virus (MDV) containing an open reading frame, whose expression is associated with lytic infection and tumor cell development in MDV-infected cells, is described. Also described is the use of this novel sequence for molecular diagnostics of serotype 1 MDV; and to generate a recombinant MDV by inserting one or more endogenous or exogenous genes, operably linked to a control element for expression, into a region of the MDV genome comprising the novel nucleotide sequence, wherein the insertion interrupts expression of the open reading frame.
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O'Connell Priscilla H.
Ohashi Kazuhiko
Schat Karel A.
Cornell Research Foundation Inc.
Fleisher Mindy
Railey II Johnny F.
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