Marek's disease herpesvirus DNA segment encoding glycoproteins,

Details Marek's disease herpesvirus DNA segment encoding glycoproteins, Marek's disease herpesvirus DNA segment encoding glycoproteins,

1991-07-25

2000-07-11

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 9141, 4351723, 4353201, 536 2372, C12P 2102, C12N 1510, C12N 1538

Patent

active

06087127&

ABSTRACT:
DNA encoding glycoproteins gD, gI and gE from Marek's disease herpesvirus is described. The DNA is useful for probes to detect the DNA in the herpesvirus, for expression to produce the glycoproteins that can be used for producing the antibodies which specifically recognize the three glycoprotein antigens, and in the case of the latter two genes, for potential insertion sites for foreign genes and as possible sites for gene inactivation to attenuate MDV field isolates for vaccine purposes.

REFERENCES:
Production of Human Beta Interferon in Insect Cells Infected With Baculovirus Expansion Vector, Smith et al., Mol. and Cell Biol., vol. 3, pp. 2156-2165, 1983.
Shih et al. PNAS, vol. 81, Sep. 1984 pp. 5867-5870.
McGeoch et al. J. Mol. Biol. vol. 181, 1985, pp. 1-13.
Cebrian et al. PNAS, vol. 79, Jan. 1982, pp. 555-558.
Fukuchi et al. J. Virol. vol. 51, 1984, pp. 102-109.

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