Map kinase integrin-binding domain

Details Map kinase integrin-binding domain Map kinase integrin-binding domain

2008-09-09

2008-09-09

Monshipouri, Maryam (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C530S324000

Reexamination Certificate

active

10451291

ABSTRACT:
Dislosed is the integrin-binding domain of MAP kinase. Interaction between MAP kinase and integrin via this domain activates MAP kinase and initiates cellular activity. Methods of modulating cellular activity by inhibiting direct MAP kinase-integrin binding are provided. These methods have particular use in inhibiting growth of cancer cells.

REFERENCES:
patent: 5593884 (1997-01-01), Karin et al.
patent: 5807746 (1998-09-01), Lin et al.
patent: 5962643 (1999-10-01), Sheppard et al.
patent: 6007991 (1999-12-01), Sivaraman et al.
patent: 6043339 (2000-03-01), Lin et al.
patent: 6248558 (2001-06-01), Lin et al.
patent: 6312956 (2001-11-01), Lane
patent: 6339148 (2002-01-01), Sheppard et al.
patent: 6432680 (2002-08-01), Lin et al.
patent: 6495518 (2002-12-01), Hawiger et al.
patent: 6576432 (2003-06-01), Sheppard et al.
patent: 6596277 (2003-07-01), Sheppard et al.
patent: 6639056 (2003-10-01), Sheppard et al.
patent: 6692741 (2004-02-01), Huang et al.
patent: 6780843 (2004-08-01), Lin et al.
patent: 6787322 (2004-09-01), Sheppard et al.
patent: WO 91/19008 (1991-12-01), None
patent: WO 92/12236 (1992-07-01), None
patent: WO 95/34295 (1995-12-01), None
patent: WO 98/16241 (1998-04-01), None
patent: WO 98/16241 (1998-04-01), None
patent: WO 99/09214 (1999-02-01), None
patent: WO 99/49879 (1999-10-01), None
patent: WO 00/59549 (2000-10-01), None
patent: WO 01/00677 (2001-01-01), None
patent: WO 01/37821 (2001-05-01), None
patent: WO 01/97827 (2001-12-01), None
Meloche, S., et al. 1992 Molecular Biology of the Cell 3: 63-71.
Liu, S. et al., “Binding of paxillin to α4integrins modifies integrin-dependent biological responses,” Nature, vol. 402, pp. 676-681 (Dec. 9, 1999).
Liu, X. et al., “Identified of a functionally important sequence in the cytoplasmic tail of integrin β3by using cell-permeable peptide analogs,” Proc. Natl Acad. USA, vol. 93, pp. 11819-11824 (Oct. 1996).
Mainiero, F. et al., “The coupling of α6β4integrin to Ras-MAP kinase pathways mediated by She controls keratinocyte proliferation,” The EMBO Journal, Oxford University Press, vol. 16, No. 9, pp. 2365-2375 (1997).
Sebolt-Leopold, J. et al., “Blockade of the Map kinase pathway suppresses growth of colon tumors in vivo,” Nature Medicine, vol. 5, No. 7, pp. 810-816 (Jul. 1999).
Gu et al (Journal of Cell biology, 1998, vol. 143, pp. 1375-1383).
Pillinger et al (PNAS, 1998, vol. 95, pp. 14540-14545).
Agrez, M.V. et al., “The αvβ6 integrin induces gelatinase B secretion in colon cancer cells,” Int. J. Cancer: 81, 90-97 (1999).
Agrez, M., et al., “The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the β6 cytoplasmic domain,” J. Cell Biol.127, No. 2, pp. 547-556 (Oct. 1994).
Ahmed, N. et al., “Direct integrin αvβ6-ERK binding: implications for tumour growth,” Oncogene 21, pp. 1370-1380 (Feb. 21, 2002).
Dedhar, S. et al., “Integrin cytoplasmic interactions and bidirectional transmembrane signalling,” Current Opnion in Cell Biology, Current Science, London, vol. 8, No. 5, pp. 657-669 (Oct. 1, 1996).
Erker, J.C. et al., Database Genbank 'Online!, “polyprotein GB virus c/Hepatitis C virus,” Database accession No. AAC55951 (Nov. 13, 1996).
Fodstad, O. et al., Database Geneseq 'Online!, “CAPL gene 5′ splice site antisense oligonucleotide,” Database accession No. AAT33333 (Nov. 12, 1996).
Hughes, P.E. et al., “Integrin affinity modulation,” Trends in Cell Biology, England, vol. 8, No. 9, pp. 359-364 (Sep. 1998).
Kerr, J.S. et al., “Novel small molecule αv integrin antagonists: comparative anti-cancer efficacy with known angiogenesis inhibitors,” Anticancer Research 19: 959-968 (1999).
Lub, M. et al., “Cytoplasmic tails of β1, β2, and β7integrins differentially regulate LFA-1 function in K562 cells,” Molecular Biology of the Cell, vol. 8, No. 4, pp. 719-728 (Apr. 1997).
Marcantonio, E.E. et al., “Mapping of the functional determinants of the integrin β1cytoplasmic domain by site-directed mutagenesis,” Cell Regulation, vol. 1, No. 8, pp. 597-604 (Jul. 1990).
Mastrangelo, A.M. et al., “Amino acid motifs required for isolated β cytoplasmic domains to regulate ‘in trans’ β1 integrin conformation and function in cell attachment,”J. Cell Science, vol. 112, No. 2, pp. 217-229 (Jan. 1999).
Meurers, B.H. et al., Database Genbank 'Online! “Myosin heavy chain 12Homo sapiens!”, Database accession No. CAA69036 (Jan. 8, 1997).
Niu, J. et al., “Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the β6 integrin subunit,” Int. J. Cancer, vol. 99, No. 4, pp. 529-537 (Jun. 1, 2002).
Oda, K. et al., Database Genbank 'Online! “CoxII intron2 ORFMarchantia polymorpha!”, Database accession No. AAC09431 (Apr. 2, 1998).
O'Toole, T.E. et al., “Regulation of integrin affinity states through an NPXY motif in the β subunit cytoplasmic domain,”J. Biol. Chem. 270, No. 15, pp. 8553-8558 (Apr. 14, 1995).
Pardi, R. et al., “Conserved regions in the cytoplasmic domains of the leukocyte integrin αLβ2are involved in endoplasmic reticulum retention, dimerization, and cytoskeletal association,” Journal of Immunology, vol. 155, No. 3, pp. 1252-1263 (Aug. 1, 1995).
Patil, S. et al, “A double mutation of the NPLY motif in the integrin β3cytoplasmic tail abolishes post-ligand binding events of β3integrins,” Molecular Biol. of the Cell, vol. 7, no. Suppl., p. 248A (Annual Mtg. of the 6thInternational Congress on Cell Biology and the 36thAmerican Society for C; San Francisco, California, US, Dec. 7-11, 1996).
Roberts, M.S. et al., “ERK1 associates with αvβ3integrin and regulates cell spreading on vitronectin,” J. Biol. Chem., vol. 278, No. 3, pp. 1975-1985 (Jan. 17, 2003).
Swanson, R. et al., Database Genbank 'Online!, “UL97 honolog 'Rhesus cytomegalovirus!”, Database accession No. AAC05259 (Mar. 7, 1998).
Tada, M. et al., Database Genbank 'Online!, “homeobox protein BIX3'Xenopus laevis!”, Database accession No. AAC61703 (Sep. 29, 1998).
Tahiliani, P.D. et al., “The role of conserved amino acid motifs within the integrin β3cytoplasmic domain in triggering focal adhesion kinase phosphorylation,”J. Biol. Chem., vol. 272, No. 12, pp. 7892-7898 (Mar. 21, 1997).
Townsend, P.A. et al., “β1 integrin antisense oligodeoxynucleotides: utility in controlling osteoclast function,” Eur. J.Cell Biol., vol. 78, pp. 485-496 (Jul. 1999).
Trikha, M. et al., “Role of αIIbβ3integrin in prostate cancer metastasis,” The Prostate, vol. 35, pp. 185-192 (1998).
Vignoud, L. et al., “NPXY motifs control the recruitment of the α5β1 integrin in focal adhesions independently of the association of talin with the β1 chain,” J. Cell Science, vo. 110, pp. 1421-1430 (Jun. 1997).
Weinacker, A. et al., Role of the integrin αvβ6in cell attachment to fibronectin, J. Biol. Chem., vol. 269, No. 9, pp. 6940-6948 (Mar. 4, 1994).
Zage, P.E. et al., “The membrane proximal region of the integrin β cytoplasmic domain can mediate oligomerization,” Cell Adhesion and Communication, vol. 5, No. 5, pp. 335-347 (1998).
Zhang, Z. et al., “Retroviral transfer of antisense integrin α6 or α8 sequences results in laminar redistribution or clonal cell death in developing brain,” J. Neuroscience, vol. 18 (17), pp. 6928-6938 (Sep. 1, 1998).
Agrez, M.V. et al., “Colorectal cancer and the integrin family of cell adhesion receptors: current status and future directions”, European Journal of Cancer 30A, 2166-2170 (1994).
Agrez, M.V. et al., “Multiplicity of fibronectin-binding αv inte

Affiliated with

Also associated with

Rating

Map kinase integrin-binding domain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Map kinase integrin-binding domain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Map kinase integrin-binding domain will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3920087