Manumycin compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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435126, 435127, 435128, 4352535, 549546, C07D30314, C07D30332, A01N 4320, A01N 3106

Patent

active

054440874

ABSTRACT:
Manumycin C, Manumycin D and Manumycin E, obtainable by cultivation of a strain of Streptomyces sp. A.T.C.C. No. 55484, oxidized derivatives thereof and salts and prodrugs of these compounds. The novel compounds have antibacterial and antitumor activity.

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Zeeck et al., "Directed Biosynthesis as An Alternative to Synthetic Modifications of Antibiotics", Antibiotics and Antiviral Compounds, Chemical Synthesis and Modification, pp. 75-87 (1993).
Kakinuma et al., "The Structure of Asukamycin, A Possible Shunt Metabolite from 3-Dehydroquinic Acid in the Shikimate Pathway," Journal of the American Chemical Society, vol. 101:12, Jun. 6, 1979, pp. 3402-3404.
Chatterjee et al., "On the Structure of Alisamycin, a New Member of the manumycin Class of Antibiotics," The Journal of Antibiotics, vol. 46, No. 6, pp. 1027-1030 (Jun. 1993).
Brodasky et al., "U-56,407, A New Antibiotic Related to Asukamycin: Isolation and Characterization," The Journal of Antibiotics, vol. 36, No. 8, pp. 950-956 (Aug. 1983).

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