Manufacturing protein microspheres

Details Manufacturing protein microspheres Manufacturing protein microspheres

1989-08-07

1991-12-03

Lovering, Richard D.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

264 41, 264 43, 424 11, 424 71, 424484, 424491, 4284022, 42840224, 514 6, 514885, 514965, 935 54, A61K 926, A61K 964, B01J 1308, B01J 1320

Patent

active

050699369

ABSTRACT:
Processes for producing biocompatible and biodegradable protein microspheres with controlled porosity and microsphere sizes are disclosed. Generally, the processes are accomplished as follows: (a) dissolving a source of protein in a mildly acidic or basic aqueous medium, in the presence or absence of a biomodifying agent, (b) adding a cross-linking reagent to the dissolved protein molecules in an amount effective subsequently to cross-link the protein molecules without gelation; (c) adding a water soluble surfactant to modify the surface of the partially cross-linked protein molecules, (d) adding a water soluble organic desolubilizer to desolubilize the protein molecules to allow cross-linkage of nearby protein molecules into water-insoluble microspheres. Alternatively, the cross-linking step of (b) is employed after desolvation of the microspheres. Incorporation of the biomodifying agent, if any, can be achieved by prior bonding to the protein molecules, addition during the formation of microspheres, or addition after the formation of the irreversible and stable microspheres. The microspheres produced by said processes are also disclosed.

REFERENCES:
patent: 3540532 (1970-11-01), Davis, Jr. et al.
patent: 3663685 (1972-05-01), Evans
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4269821 (1981-05-01), Kreuter et al.
Martodam et al., "Albumin Microspheres as Carrier . . . ", Proc. Natl. Acad. Sci. U.S.A., 76 (1979) pp. 2128-2132.
Widder et al.: "Magnetically Responsive Microspheres . . . ", Advances in Pharmacology and Chemotheraphy, vol. 16 (1979) pp. 213-271.

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