Manufacturing process for N-carbobenzyloxy-L-glutamic acid-.alph

Details Manufacturing process for N-carbobenzyloxy-L-glutamic acid-.alph Manufacturing process for N-carbobenzyloxy-L-glutamic acid-.alph

1984-08-13

1985-11-12

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C125065

Patent

active

045529752

ABSTRACT:
The invention relates to manufacturing process for a halide or an organic sulfonate of N-carbobenzyl-L-glutamic acid-.alpha.-cholinester in high purification, which is useful as e.g. hypotensive drug. According to the prior art, undesired .gamma.-form byproduct is inevitably formed to be mingled with said .alpha.-form objective compound of which separation is difficult. It has been found that when using N-carbobenzyloxy-.gamma.-tert. butyl-L-glutamic acid-dicyclohexyl-ammonium salt readily available in high purification as starting material, reacting N, N-dimethyl-aminoethylchloride therewith to form N-carbobenzyloxy-.gamma.-tert. butyl-L-glutamic acid-.alpha.-dimethylaminoethyl ester which is quaternerized to form N-carbobenzyloxy-.gamma.-tert. butyl-L-glutamic acid-.alpha.-cholinester salt, which is subjected to mild salt treatment, the objective compound can be obtained in high purification.

Affiliated with

Also associated with

Rating

Manufacturing process for N-carbobenzyloxy-L-glutamic acid-.alph does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Manufacturing process for N-carbobenzyloxy-L-glutamic acid-.alph, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Manufacturing process for N-carbobenzyloxy-L-glutamic acid-.alph will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1881106