Manufacturing process for methyl phenidate and intermediates...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S317000, C546S238000, C546S233000

Reexamination Certificate

active

07459467

ABSTRACT:
The present invention discloses selective and complete reduction of pyridine ring in a biaryl system comprising ∝-substituted or non-substituted benzene ring and relates more specifically, not exclusively, for the manufacture of methylphenidate, which is used for treatment of Attention Deficit Hyperactive Disorder (ADHD) and also acts as central nervous system stimulant, by using palladium/C in a solvent such as C1-C4 alcohols in presence of molar quantities of organic and/or inorganic acids.

REFERENCES:
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Deutsch et al., J. Med. Chem., 1996, 39, 1201-1209.
Freifelder, J. Org. Chem.,1964, 29(10), 2895-2898.
Chung et al., J. Org. Chem.,1996, 61, 215-222.
Zacharie et al. (J. Org. Chem.,2001, 66, 5264-5265.

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