Chemistry: analytical and immunological testing – Optical result – Including reagent preparation
Patent
1997-08-07
1998-12-08
Alexander, Lyle A.
Chemistry: analytical and immunological testing
Optical result
Including reagent preparation
156264, 156324, G01N 3348
Patent
active
058468358
ABSTRACT:
The invention relates to a method of making a laminated substrate for use in an immunodiagnostic device and a machine or apparatus for marking the substrate with reagent. The method of forming the laminated substrate creates a rollable chromatographic medium. The chromatographic medium can be biphasic or multiphasic. The biphasic chromatographic medium comprises a capture medium precast onto a plastic backing and a release medium. The release and capture media are bonded to a liner material such as a plastic film. The multiphasic chromatographic medium comprises a capture medium precast onto a plastic backing, a release medium, and a sample absorbent medium. The capture medium, the release medium and the sample absorbent medium are disposed on a liner material such as a plastic film. The biphasic and multiphasic laminates are prepared for use as immunoassays by a specially adapted machine or apparatus. The machine includes a leader, an unwind system, a reagent dispensing system, a substrate reject marking system, a drying system, and a rewind system. In one exemplary embodiment, the machine applies four reagents to the substrate. The particular reagents used in the machine will vary depending upon the immunoassay to be performed.
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Nazareth Albert R.
Sisbarro Fredrick P.
Thomsen Glenn W.
Alexander Lyle A.
Carter Wallace, Inc.
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