Manufacturing method and apparatus for biological probe arrays u

Details Manufacturing method and apparatus for biological probe arrays u Manufacturing method and apparatus for biological probe arrays u

1994-09-23

1997-02-11

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352862, 4352864, 4352865, 4353091, 4352831, 422 63, 422100, 436 55, 436 63, 436807, 436809, G01N 3510

Patent

active

056019807

ABSTRACT:
A method and apparatus is provided for spotting a biological probe onto an array. A micropipette containing a quantity of the biological probe in solution is manipulated to a position above a selected location within the array. The micropipette is pressurized sufficiently to produce a droplet of the biological probe at an open tip of the micropipette. Formation of the droplet is simultaneously visually monitored during the pressurization of the micropipette in order to estimate a volume measurement of the droplet. Upon reaching a predetermined volume for the droplet, the pressurizing of the micropipette is discontinued. The droplet of the predetermined volume is then dispensed onto the selected location.

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