Manufacturing intravenous tolerable immunoglobulin-G preparation

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530380, 5303894, 5303895, 5303905, C07K 1514

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active

051644878

ABSTRACT:
Method of manufacturing an intravenously tolerable immunoglobulin-G preparation that is free of aggregates, vasoactive substances and proteolytic enzymes and accordingly appropriate for all types of patients, especially immunosuppressed patients, from a starting material that contains immunoglobulin G but from which the coagulation factors have been removed. The starting material is treated with 0.4 to 1.5% by volume of octanoic acid and then chromatographed, especially on an ion or cation exchanger or hydrophobic matrix.

REFERENCES:
patent: 3916026 (1975-10-01), Stephan
patent: 4939176 (1990-07-01), Serg et al.
Journal of Immunological Methods, vol. 65, 1983, Holland, pp. 269-271; Russo, C. et al: "Purification of IgG monoclonal antibody by caprylic acid precipitation".
Chemical Abstracts, vol. 103, No. 13, Sep. 1985, Columbus, Ohio, USA, Goheen, S.C. et al.: "Purification of human serum gamma globulins by hydrophic interaction high-performance liquid chromatography", p. 458; Col. 1, Ref. No. 103013.
Vox Sang. 52: 281-290 (1987), "An Animal Model for the Detection of Hypotensive Side Effects of Immunoglobulin Preparations".
Thrombosis Research 31, 351-364, 1983, "Prekallikrein, HMW-Kininogen and Factor XII in Various Disease States".
Archives of Biochemistry and Biophysics 134, pp. 279-284 (1969), "The Isolation of IgG from Mammalian Sera with the Aid of Caprylic Acid".
Archives of Biochemistry and Biophysics, vol. 89, 1960, pp. 218-220; Chanutin A. et al.: "The precipitation of plasma proteins by short-chain fatty acids".
Preparative Biochemistry, vol. 14, No. 1, 1984, pp. 1-17; Habeeb, A. et al: "Preparation of human immunolglobulin by caprylic acid precipitation".
Develop. biol. Standard, vol. 67, pp. 257-265 (S. Karger, Basel, 1987).
Habeeb and Francis, Prep. Biochem. 14(1) 1-17, 1984. Preparation of Human Immunoglobulin.
Vox Sang, 23165-175, 1972. Pejaudier et al. Preparation of Human IgA as a By-Product of Routine Fractionation.

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