Manufacture of water-swellable hydrophilic articles and drug del

Details Manufacture of water-swellable hydrophilic articles and drug del Manufacture of water-swellable hydrophilic articles and drug del

1993-03-31

1994-03-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 264310, 264311, 264255, 264267, 604 59, A61M 5178

Patent

active

052925153

ABSTRACT:
A method of preparing a hydrophilic plastic cartridge by centrifugally cang polymerizable hydrophilic material in a rotating polymerization tube whose longitudinal axis is maintained parallel to the ground. The speed of rotation causes radial outward displacement of the polymerizable material which upon assuming a predetermined shape within the rotating tube is then polymerized to the predetermined solid configuration. The resulting plastic cartridge is characterized by smooth, unscored internal and external cylindrical surfaces. The cartridges are used as a rate-limiting membrane in drug delivery devices. Sterilized kits containing a disposable needle/syringe or trocar-like instrument and the drug delivery device are used for subcutaneous implantation of the device in an animal body.

REFERENCES:
patent: 2513014 (1950-06-01), Fields
patent: 3921632 (1975-11-01), Bardani
patent: 4846793 (1989-07-01), Leonard
patent: 4871094 (1988-04-01), Gall
patent: 4959217 (1990-09-01), Sanders
patent: 4994028 (1991-02-01), Leonard
patent: 5004614 (1991-04-01), Staniforth
patent: 5035891 (1991-07-01), Runkel

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